Early life experience alters response of adult neurogenesis to stress

By Christian Mirescu, Jennifer D. Peters, E. Gould. Nature Neuroscience, 2004

680 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/fc0389b473ba7de6e7107f1d60b7300b56dbf277

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Citations in the corpus

Evolution and ontogeny of stress response to social challenges in the human child (2006, background): “Hence early trauma is posited to result in permanent HPA dysregulation and hypercortisolemia, with consequent deleterious eVects on the hippocampus, thymus, and other key neural, metabolic, and immune system components (Mirescu et al., 2004; Zhang, Parent, Weaver, & Meaney, 2004).”
Behavior problems and mental health referrals of international adoptees: a meta-analysis. (2005, background): “separation and deprivation can seriously harm infant functioning and later development.(8,9) Psychological deprivation in orphanages can result in maladjustment in children.”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “prolonged effects on adult neurogenesis and hippocampus-mediated stress responses [28], suggesting”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, neutral): “Interestingly, maternal separation in rodents induces reduced mossy fiber density and impaired neurogenesis in the hippocampus (Huot et al., 2002; Mirescu et al., 2004).”
Neural Bases of Cognitive Development (2007, background): “Particularly relevant to this chapter is the observation that the addition of such cells can be influenced by experience (e.g., Gould et al., 1999; Mirescu, Peters, & Gould, 2004).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “In addition, adverse experience early in life, in the form of maternal separation, produces a decrease in cell proliferation and immature neuron production in the dentate gyrus of adult rat”
Structural Plasticity and Hippocampal Function (2010, background): “Likewise, adult rats subjected to maternal separation in early life exhibit reduced neurogenesis (Mirescu et al. 2004).”
Stress and adult neurogenesis (2006, background): “For instance, stressors occurring early in life have been shown to decrease cell proliferation (Lemaire et al., 2000; Mirescu et al., 2004) not only at the time of stress (Tanapat et al.”
The developing brain and neural plasticity: Implications for normality, psychopathology, and resilience. (2015, background): “Mirescu, Peters, and Gould (2004) demonstrated that early adversity affects the regulation of adult neurogenesis in the hippocampus.”
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “Glucocorticoids and stress are known to inhibit the production of cells from the EGL resulting in decreased size and cell content of the molecular and/or granular layers of the mature cerebellum, depending on the timing of exposure (414, 469, 772).”
Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education (2019, neutral): “…(Eriksson et al., 1998; Lledo, Alonso, & Grubb, 2006; Zhao, Deng, & Gage, 2008), but this growth can be inhibited by stress (Mirescu & Gould, 2006; Mirescu, Peters, & Gould, 2004), chronic sleep disruption (Lucassen et al., 2010; Meerlo, Mistlberger, Jacobs, Heller, & McGinty, 2009), or dietary…”
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (2006, background): “Stress-related malfunction of the HPA axis, with no differences in basal levels of corticosterone, impairs adult neurogenesi”
The current state of the neurogenic theory of depression and anxiety. (2015, background): “In a model of childhood neglect, a risk factor for mood and anxiety disorders, young rats separated from their mothers have both increased anxiety in adulthood [19] and decreased AHN [20].”