Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men.
By Youfa Wang, E. Rimm, MR Stampfer, W. Willett, F. B. Hu. American Journal of Clinical Nutrition, 2005
1,182 citations recorded by the source corpus.
BACKGROUND Obesity is a strong risk factor for type 2 diabetes. However, few studies have compared the predictive power of overall obesity with that of central obesity. The cutoffs for waist circumference (WC) and waist-to-hip ratio (WHR) as measures of abdominal adiposity remain controversial. OBJECTIVE The objective was to compare body mass index (BMI), WC, and WHR in predicting type 2 diabetes. DESIGN A prospective cohort study (Health Professionals Follow-Up Study) of 27 270 men was conducted. WC, WHR, and BMI were assessed at baseline. Covariates and potential confounders were assessed repeatedly during the follow-up. RESULTS During 13 y of follow-up, we documented 884 incident type 2 diabetes cases. Age-adjusted relative risks (RRs) across quintiles of WC were 1.0, 2.0, 2.7, 5.0, and 12.0; those of WHR were 1.0, 2.1, 2.7, 3.6, and 6.9; and those of BMI were 1.0, 1.1, 1.8, 2.9, and 7.9 (P for trend < 0.0001 for all). Multivariate adjustment for diabetes risk factors only slightly attenuated these RRs. Adjustment for BMI substantially attenuated RRs for both WC and WHR. The receiver operator characteristic curve analysis indicated that WC and BMI were similar and were better than WHR in predicting type 2 diabetes. The cumulative proportions of type 2 diabetes cases identified according to medians of BMI (>/=24.8), WC (>/=94 cm), and WHR (>/=0.94) were 82.5%, 83.6%, and 74.1%, respectively. The corresponding proportions were 78.9%, 50.5%, and 65.7% according to the recommended cutoffs. CONCLUSIONS Both overall and abdominal adiposity strongly and independently predict risk of type 2 diabetes. WC is a better predictor than is WHR. The currently recommended cutoff for WC of 102 cm for men may need to be reevaluated; a lower cutoff may be more appropriate.
Subfields: Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Surgery
View Paper: https://www.semanticscholar.org/paper/ce0f84a689168f1c38fbe580b49be4e851f99c0e
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Citations in the corpus
- An integrated framework for local genetic correlation analysis (2022, background): “Although BMI and WHR have both been implicated in T2D etiology 41,42 , BMI measures the total body mass, whereas WHR measures its distribution 41 .”
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- Association of sleep apnea and type II diabetes: a population-based study. (2005, background): “We found that waist girth was the body habitus measure with the best correlation with diabetes, which was consistent witharecent report (19).”
- Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies (2016, background): “42 y) [15], and the Health Professionals Follow-Up Study (HPFS) started in 1986 with 51,529 male health professionals (aged 40–75 y) [16]; all three studies recruited participants from across the US.”
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