The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
By D. Guh, Wei Zhang, N. Bansback, Z. Amarsi, C. Birmingham, Aslam H Anis. BMC Public Health, 2009
3,644 citations recorded by the source corpus.
BackgroundOverweight and obese persons are at risk of a number of medical conditions which can lead to further morbidity and mortality. The primary objective of this study is to provide an estimate of the incidence of each co-morbidity related to obesity and overweight using a meta-analysis.MethodsA literature search for the twenty co-morbidities identified in a preliminary search was conducted in Medline and Embase (Jan 2007). Studies meeting the inclusion criteria (prospective cohort studies of sufficient size reporting risk estimate based on the incidence of disease) were extracted. Study-specific unadjusted relative risks (RRs) on the log scale comparing overweight with normal and obese with normal were weighted by the inverse of their corresponding variances to obtain a pooled RR with 95% confidence intervals (CI).ResultsA total of 89 relevant studies were identified. The review found evidence for 18 co-morbidities which met the inclusion criteria. The meta-analysis determined statistically significant associations for overweight with the incidence of type II diabetes, all cancers except esophageal (female), pancreatic and prostate cancer, all cardiovascular diseases (except congestive heart failure), asthma, gallbladder disease, osteoarthritis and chronic back pain. We noted the strongest association between overweight defined by body mass index (BMI) and the incidence of type II diabetes in females (RR = 3.92 (95% CI: 3.10–4.97)). Statistically significant associations with obesity were found with the incidence of type II diabetes, all cancers except esophageal and prostate cancer, all cardiovascular diseases, asthma, gallbladder disease, osteoarthritis and chronic back pain. Obesity defined by BMI was also most strongly associated with the incidence of type II diabetes in females (12.41 (9.03–17.06)).ConclusionBoth overweight and obesity are associated with the incidence of multiple co-morbidities including type II diabetes, cancer and cardiovascular diseases. Maintenance of a healthy weight could be important in the prevention of the large disease burden in the future. Further studies are needed to explore the biological mechanisms that link overweight and obesity with these co-morbidities.
Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Surgery
View Paper: https://www.semanticscholar.org/paper/06bc35e6b33ffdad79a7506a26d255e55c810117
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In Cardiology and Cardiovascular Medicine
In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “Very recently, in a systematic review of 18 weight-related diseases, the investigators found that diabetes is at the top of the risk list: men with BMI ‡30 had a 7-fold and women with BMI ‡30 had a 12-fold higher risk of developing type 2 diabetes compared with men and women in the normal weight ran”
- 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery. (2022, background): “They include the cardiovascular system (hypertension, dyslipidemia, coronary artery disease, heart failure, stroke), respiratory system (obstructive sleep apnea, asthma), digestive system (gastroesophageal reflux disease, gallbladder disease, pancreatitis), endocrine system (insulin resistance, T2D)”
- The health status of adults on the autism spectrum (2015, background): “Poor, restricted diets and lack of exercise are risk factors for obesity, which in turn is associated with increased risk of many major chronic conditions (Guh et al., 2009).”
- Adipose tissue and adipocytes supports tumorigenesis and metastasis (2013, background): “major risk factor for metabolic disease including type 2 diabetes, cardiovascular disease, and cancer [18].”
- Obesity: Risk factors, complications, and strategies for sustainable long‐term weight management (2017, background): “Obesity is a chronic disease that is associated with a wide range of complications affecting many different aspects of physiology (Dobbins, Decorby, & Choi, 2013; Guh et al., 2009; Martin-Rodriguez, Guillen-Grima, Marti, & BrugosLarumbe, 2015; summarized in Table 1).”