Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential

By Andrew P. Desbois, V. Smith. Applied Microbiology and Biotechnology, 2010

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Impact of Omega-3 Fatty Acids on the Gut Microbiota (2017, background): “Unsaturated fatty acids tend to have greater activity than saturated fatty acids with the same length carbon chain [51].”
Current Limitations and Challenges with Lactic Acid Bacteria: A Review (2013, background): “Fatty acids have many well defined biological functions [56]; however, there are limited data on the roles of fatty acids and fats as growth factors for LAB [56] [57] [58].”
The Use of Microalgae and Cyanobacteria in the Improvement of Agricultural Practices: A Review on Their Biofertilising, Biostimulating and Biopesticide Roles (2021, background): “activities, which make them promising candidates for the development of pharmaceutical, nutraceutical and cosmetic products [2,7,30,31].”
The Various Roles of Fatty Acids (2018, background): “Whilst their antibacterial mode of action is poorly understood, free FA acting upon the cell membrane can disrupt the electron transport chain and oxidative phosphorylation [107].”
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “…response of fat tissue to bacterial antigens such as lipopolysaccharide may combine with high local concentrations of fatty acids during ensuing cytokine-induced lipolysis to mitigate infection (Chung et al., 2006; Desbois and Smith, 2010; Tchkonia et al., 2006a; Thomou et al., 2010).”