Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

By M. Lutolf, J. Lauer-Fields, H. Schmoekel, A. Metters, F. Weber, G. Fields, J. Hubbell. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,412 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/ccd9348fa0b1c1a0a035faa35d54cb40cbb79bba

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In Biomedical Engineering

In Cancer Research

In Surfaces, Coatings and Films

Citations in the corpus

Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. (2010, background): “1E, F)) and ECM [8,52], but also induces the physical constraint experienced by cells in 3D [22,28,29].”
Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends (2007, background): “Growth factors can be entrapped that can also promote mesenchymal stem cell (MSC) inﬁltration and corresponding differentiation (Lutolf et al .”
Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering (2010, neutral): “GPQGYIAGQ Collagen-I MMP-1 Dithiol [161]”
Bone tissue engineering: state of the art and future trends. (2004, positive): “This third generation of biomaterials is based on the molecular modifications of resorbable polymeric systems that will later stimulate specific interactions with cell integrins and thereby direct cell proliferation, differentiation and extracellular matrix production and organization [294-296].”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “Here, PEG macromers are covalently conjugated with cell adhesive and proteolytic cleavage ligands such as matrix metalloproteinase (MMP) degradation sites.(118) Cells cultured within this modified PEG-based hydrogel can grow and migrate deep into the matrix, creating spaces after local matrix degrad”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “PEG gels and their derivatives have been used in a variety of 3D cell culture applications including stem cell differentiation, cell invasion and angiogenesis (Lutolf et al., 2003; Moon et al., 2010; Zhu, 2010; Caiazzo et al., 2016).”
Advances in engineering hydrogels (2017, positive): “To achieve this functionality within a hydrogel, a specially designed linker moiety typically sensitive to an enzyme can be copolymerized into the hydrogel so as to allow for localized proteasemediateddegradationof thepolymericnetwork (79).”