Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends

By J. Mano, G. Silva, H. Azevedo, P. Malafaya, R. A. Sousa, S.S Silva, L. Boesel, J. Oliveira, T. C. Santos, A. Marques and 2 more. Journal of the Royal Society Interface, 2007

1,081 citations recorded by the source corpus.

The fields of tissue engineering and regenerative medicine aim at promoting the regeneration of tissues or replacing failing or malfunctioning organs, by means of combining a scaffold/support material, adequate cells and bioactive molecules. Different materials have been proposed to be used as both three-dimensional porous scaffolds and hydrogel matrices for distinct tissue engineering strategies. Among them, polymers of natural origin are one of the most attractive options, mainly due to their similarities with the extracellular matrix (ECM), chemical versatility as well as typically good biological performance. In this review, the most studied and promising and recently proposed naturally derived polymers that have been suggested for tissue engineering applications are described. Different classes of such type of polymers and their blends with synthetic polymers are analysed, with special focus on polysaccharides and proteins, the systems that are more inspired by the ECM. The adaptation of conventional methods or non-conventional processing techniques for processing scaffolds from natural origin based polymers is reviewed. The use of particles, membranes and injectable systems from such kind of materials is also overviewed, especially what concerns the present status of the research that should lead towards their final application. Finally, the biological performance of tissue engineering constructs based on natural-based polymers is discussed, using several examples for different clinically relevant applications.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/5026cec40871def40a7d0dfbe90cd3ba88ee0a89

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Citations in the corpus

• The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues (2010, background): “also studied the morphology, growth, adhesion, motility, and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells on EDC cross-linked electrospun collagen fibrous mats [14].”
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• Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration (2010, background): “porous scaffolds by dissolution in water-based solutions and subsequent freeze-drying [63, 64].”
• A review of key challenges of electrospun scaffolds for tissue‐engineering applications (2016, background): “Contrary to synthetic polymers, natural polymers have more similarities with ECM, and their favourable biological performance allows for the induction of an appropriate cell response (Mano et al., 2007).”
• Unprecedented Chitin and Chitosan: A Chemical Overview (2013, background): “One of their most important features is the ability (flexibility) to be shaped into different forms such as fibers, hydrogels, beads, sponges, and membranes[28].”