Bone tissue engineering: state of the art and future trends.

By A. Salgado, O. Coutinho, Rui Luís Reis. Macromolecular Bioscience, 2004

1,713 citations recorded by the source corpus.

Although several major progresses have been introduced in the field of bone regenerative medicine during the years, current therapies, such as bone grafts, still have many limitations. Moreover, and in spite of the fact that material science technology has resulted in clear improvements in the field of bone substitution medicine, no adequate bone substitute has been developed and hence large bone defects/injuries still represent a major challenge for orthopaedic and reconstructive surgeons. It is in this context that TE has been emerging as a valid approach to the current therapies for bone regeneration/substitution. In contrast to classic biomaterial approach, TE is based on the understanding of tissue formation and regeneration, and aims to induce new functional tissues, rather than just to implant new spare parts. The present review pretends to give an exhaustive overview on all components needed for making bone tissue engineering a successful therapy. It begins by giving the reader a brief background on bone biology, followed by an exhaustive description of all the relevant components on bone TE, going from materials to scaffolds and from cells to tissue engineering strategies, that will lead to "engineered" bone. Scaffolds processed by using a methodology based on extrusion with blowing agents.

Subfields: Biomaterials, Biomedical Engineering, Rheumatology

View Paper: https://www.semanticscholar.org/paper/964d0e2d714e93105c47781e1879579f93bf35fc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. Ali Khademhosseini
2. N. Annabi
3. Jihua Li
4. A. Ferreira
5. Y. Zuo
6. D. Kumar
7. Huanan Wang
8. Lin Cheng

In Biomedical Engineering

1. N. Annabi
2. Ali Khademhosseini
3. Hojae Bae
4. Jihua Li
5. M. Nikkhah
6. Y. Zuo
7. D. Kumar
8. Huanan Wang

In Rheumatology

1. Magdi Yacoub
2. I. El-Sherbiny

Citations in the corpus

• Collagen for bone tissue regeneration. (2012, background): “some cases, potential risk of transmitting animal-originated pathogens [48,49,51].”
• Current development of biodegradable polymeric materials for biomedical applications (2018, background): “115 Lately, further improvements have been made to these starch-based scaffolds.”
• Bone regeneration: current concepts and future directions (2011, background): “This alternative treatment of conditions requiring bone regeneration could overcome the limitations of current therapies, by combining the principles of orthopaedic surgery with knowledge from biology, physics, materials science and engineering, and its clinical application offers great potential [5”
• 3D bioactive composite scaffolds for bone tissue engineering (2017, neutral): “amples of growth factors that have been utilised in bone and cartilage tissue engineering [36,37].”
• Fiber reinforcement during 3D printing (2015, background): “A practical limitation of 3D printing is the relatively low initial green sample strength, which can lead to a collapse of large structures during removal from the powder bed and the following depowdering procedure [4].”
• POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING APPLICATION: A REVIEW (2011, background): “Pore interconnectivity is also critical to ensure that all cells are within 200 μm from blood supply in order to provide for mass transfer of oxygen and nutrients [224, 227].”
• An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering (2014, background): “In contrast, biodegradable polymers present appropriate characteristics, in terms of physico-chemical and biological properties, suitable to fabricate scaffolds for tissue engineering (TE) [8].”
• Vascularized Bone Tissue Engineering: Approaches for Potential Improvement (2012, background): “Allografts can be used for larger defects but are limited by the possible immune rejection, disease transmission, and lower incorporation rate compared to autografts.(1) Xenografts are rarely used since they share the same drawbacks as allografts and their physiological structures and functions do n”
• Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective (2013, neutral): “Osteogenic cells migrate to the scaffold surface through a fibrin clot initially established immediately after implantation of the TEC from the haematoma caused by the surgical procedure (101).”