Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

By C. Raiborg, Kristi G. Bache, D. Gillooly, I. H. Madshus, E. Stang, Harald A. Stenmark. Nature Cell Biology, 2002

736 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ccb770179bbdcb977823d8972aa6ddee838be945

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Harald A. Stenmark
2. C. Raiborg
3. Ivan Dikic
4. T. Balla
5. Robert C. Piper
6. Tony Pawson
7. David J. Katzmann
8. Ari Helenius

In Immunology

1. T. Balla
2. Ari Helenius
3. Ivan Dikic

In Molecular Biology

1. Ivan Dikic
2. Harald A. Stenmark
3. C. Raiborg
4. Tony Pawson
5. T. Balla
6. Robert C. Piper
7. David J. Katzmann
8. Pier Paolo Di Fiore

Citations in the corpus

• Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor (2004, background): “Many of these endosomes have electron-dense deposits resembling the previously described bilayered clathrin-and Hrs-containing coats (Ra-poso et al., 2001; Raiborg et al., 2002, 2003; Sachse et al., 2002).”
• Post-translational modifications in signal integration (2010, background): “Proteins such as hepatocyte growth factor–regulated tyrosine kinase substrate protein (HRS) or signal-transducing adapter molecules 1 and 2 (STAM1 and STAM2) recruit ubiquitinated EGFR through their UIM”
• Ubiquitin-binding domains (2005, background): “Consistent with the multiple roles of ubiquitin in endocytosis, numerous UBDs are also required in this proces”
• Biogenesis and function of multivesicular bodies. (2007, background): “The Hrs-STAM complex works in parallel with GGA proteins as well as the Tom1-Tollip complex to bind, retain, and concentrate Ub-cargo on endosomal subdomains (Raiborg et al. 2002).”
• Endosome maturation (2011, background): “…cytosolic surface of the EE membrane has characteristic ‘plaques’ containing clathrin and components of the endosomal sorting complex required for transport (ESCRT), machinery responsible for sorting of ubiquitinated membrane proteins into ILVs (Raiborg et al, 2002; Sachse et al, 2002) (Figure 3B).”
• Ubiquitylation and cell signaling (2005, background): “…and tumor susceptibility gene 101 (TSG101), which are localized The EMBO Journal VOL 24 | NO 19 | 2005 &2005 European Molecular Biology Organization3354 in specific endocytic compartments and can direct the endosomal sorting of the ubiquitylated cargo (Raiborg et al, 2002; Hicke and Dunn, 2003).”
• The emerging shape of the ESCRT machinery (2007, background): “HRS also binds ubiquitin via a ubiquitin-interacting motif (UIM), which is essential for efficient sorting of ubiquitylated membrane protein”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Accordingly, PtdIns3P exerts its effects by recruiting a variety of proteins that contain PI binding domains that are attracted to the membrane by this particular PPI species.”
• The ESCRT pathway. (2011, background): “Accordingly, ESCRT complexes have several distinct ubiquitin-binding motifs (Bilodeau et al., 2002; Hirano et al., 2006; Mizuno et al., 2003; Pornillos et al., 2002; Raiborg et al., 2002; Shields et al., 2009; Shih et al., 2002; Slagsvold et al., 2005).”