Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

By R. Shibata, Kaori Sato, D. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi, K. Walsh. Nature Medicine, 2005

1,018 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “Adiponectin protects the myocardium from injury by protecting cardiac muscle cells from apoptosis through activation of AMPK signallin”
Adipocytokines in Obesity and Metabolic Disease (2014, positive): “In addition, adiponectin exhibits cardioprotective activity in ischemic heart disease through AMPK and cyclooxygenase 2 pathways (Shibata et al. 2005).”
Cardiac remodeling in obesity. (2008, background): “Administration of adiponectin diminished the infarct size, apoptosis, and TNF- production induced by ischemia-reperfusion in both wild-type and adiponectin KO mice (321).”
Adiponectin Regulation and Function (2018, positive): “Following myocardial-ischemia injury, adiponectin knockout mice develop larger infarcts, which are diminished after adenovirus-mediated delivery of adiponectin (300).”
Omega-3 polyunsaturated fatty acids and cardiovascular diseases. (2009, background): “Recent evidence suggests that ligand activation of PPAR-gamma by EPA and/or DHA up-regulates adiponectin and suppression of inflammatory cytokines (48–50), which could improve cardiac structure and function in HF (51,52).”
Adipose tissue-derived factors: impact on health and disease. (2006, neutral): “diac dysfunction in ischemic-reperfusion injury (100).”