From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

By O. Schmidt-Kittler, Thomas Ragg, A. Daskalakis, Martin Granzow, A. Ahr, T. Blankenstein, M. Kaufmann, J. Diebold, H. Arnholdt, P. Müller and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

646 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/cbc6695309664d7dcc7bae42b6e412553de52ada

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In Cancer Research

1. J. Massagué
2. K. Pantel
3. J. Aguirre-Ghiso
4. A. Marusyk
5. K. Polyak
6. Ruud H. Brakenhoff
7. Yibin Kang
8. D. Nguyen

In Oncology

1. J. Massagué
2. R. Weinberg
3. D. Nguyen
4. K. Pantel
5. J. Aguirre-Ghiso
6. Larry Norton
7. K. Polyak
8. Yibin Kang

In Pathology and Forensic Medicine

1. J. Massagué
2. D. Nguyen
3. G. Gupta
4. K. Pantel

Citations in the corpus

• Genetic determinants of cancer metastasis (2007, background): “Tumour cells found in the marrow during early disease progression share few chromosomal aberrations with their corresponding primary tumour”
• Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “Additionally, although some studies have documented extensive molecular differences between patient-matched primary breast tumors and metastases (Schmidt-Kittler et al., 2003),”
• Tumor heterogeneity: causes and consequences (2009, background): “These cells contained surprisingly few chromosomal aberrations [96], while higher-resolution LOH analysis did confirm the neoplastic origin of these cells and pointed to early events in tumor progression [97].”
• Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. (2005, background): “It is unclear whether these metastasis genes are acquired during the growth of the primary tumor or during colonization at a distant site (17).”
• Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. (2008, background): “Specifically, Klein and colleagues have reported that disseminated cancer cells in the bone marrow of breast cancer patients exhibit different and fewer alterations than their matched primary tumors (Schmidt-Kittler et al., 2003; Schardt et al., 2005).”
• Dissecting the metastatic cascade (2004, background): “In patients with early-stage invasive breast cancer, the cytokeratin-positive cells isolated from the bone marrow had few features in common with those found in their respective primary tumour”
• Latent bone metastasis in breast cancer tied to Src-dependent survival signals (2009, background): “Nearly one-third of cases of relapse emerge after 3 years of breast cancer diagnosis, with some cases emerging several decades later (Karrison et al., 1999; Schmidt-Kittler et al., 2003).”
• Metastasis: from dissemination to organ-specific colonization (2009, background): “Breast cancer recurrences are often detected following years or decades of remissio”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “…for example, undergo dissemination from an early stage (Husemann et al., 2008; Klein et al., 1999), but metastasis to bones, lungs, brain, or liver may not manifest until years or decades after the diagnosis and removal of the primary tumor (Karrison et al., 1999; Schmidt-Kittler et al., 2003).”