Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.

By Andy J. Minn, Yibin Kang, I. Serganova, G. Gupta, D. Giri, M. Doubrovin, V. Ponomarev, W. Gerald, R. Blasberg, J. Massagué. Journal of Clinical Investigation, 2005

737 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5a0f8f478454f1abf85885b023e525920c334c4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. R. Weinberg
2. A. Richardson
3. Z. Wang
4. A. Szász
5. J. Massagué
6. Ferenc Reinhardt
7. J. Brock
8. Diana Calogrias

In Molecular Biology

1. R. Weinberg
2. J. Massagué
3. D. Nguyen
4. X. Zhang
5. Scott Valastyan
6. Larry Norton
7. Paula D. Bos
8. Thordur Oskarsson

In Oncology

1. R. Weinberg
2. J. Massagué
3. D. Nguyen
4. Charles M. Perou
5. Ferenc Reinhardt
6. X. Zhang
7. Larry Norton
8. Thordur Oskarsson

Citations in the corpus

• Revisiting the hallmarks of cancer. (2017, neutral): “[131] Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R and Massagué J.”
• Genetic determinants of cancer metastasis (2007, background): “Consistent with the selectivity of metastatic progression, these different cell variants were found to already exist in the parental, unselected populatio”
• Triple Negative Breast Cancer Cell Lines: One Tool in the Search for Better Treatment of Triple Negative Breast Cancer (2010, background): “the genes identified for each site of metastasis to create gene signatures, the investigators were able to identify tumors that preferentially metastasized to each site from human tumor samples [89, 91, 92].”
• Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy (2008, background): “Moreover, single cell clones derived from the same cancer cell line are not equally tumorigenic or metastatic [34-36].”
• Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, positive): “This view has been corroborated by a number of investigations [85-88].”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, methodology): “NSCLC cell lines were engineered to stably express a triple modality vector encoding GFP-luciferase fusion (Minn et al., 2005b).”
• Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy (2006, background): “Today, transcriptome studies in mouse models of cancer and in human tumour samples continue to highlight the important roles of MMPs in metastatic disease, especially in highly aggressive late-stage tumours with poor clinical outcom”
• Tumor self-seeding by circulating cancer cells (2009, methodology): “Enhanced angiogenesis and increased recruitment of neutrophils and macrophages accompanied the seeded areas of these tumors, and seeder-derived CXCL1, which is another marker of poor prognosis in ER breast cancer (Minn et al., 2005a, 2007), was partly responsible for this recruitment.”
• CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis (2006, methodology): “such as bone and lung have revealed a distinct gene expression pattern associated with metastasis to these sites [14,15].”