Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution

By Jill Cheng, Philipp Kapranov, J. Drenkow, S. Dike, Shane A. Brubaker, Sandeep Patel, J. Long, D. Stern, H. Tammana, G. Helt and 9 more. Science, 2005

1,206 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/cbaf2184e93857a02f2b4ac23ecc5302bf2f0642

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Citations in the corpus

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs (2013, background): “In fact, earlier tiling array studies revealed that intergenic transcripts tend to be bimorphic; that is, they appear in both polyA+ and polyA2 fractions, as opposed to protein coding transcripts that are primarily polyA+ [3].”
LocARNA-P: accurate boundary prediction and improved detection of structural RNAs. (2012, background): “2001; Lee and Ambros 2001) and the advent of genome-wide transcriptomics (Bertone et al. 2004; Cheng et al. 2005; The FANTOM Consortium et al. 2005), it has become obvious that RNA’s crucial role in living cells extends far beyond being a mere template for protein biosynthesis.”
Circular intronic long noncoding RNAs. (2013, background): “It is known that a significant fraction of long Pol II transcripts may lack a canonical poly(A) tail (Cheng et al., 2005; Wu et al., 2008; Yang et al., 2011).”
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “fact, many lncRNA genes have two or more exons [32] and about 60% of lncRNAs have polyA+ tails [38] (Figure 1).”
The UCSC Genome Browser Database: update 2006 (2005, methodology): “The human Genome Browser displays the Affymetrix Transcriptome Project Phase 2 (43) data in the Affy Txn Phase2 track.”
Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities (2008, background): “In humans and mice, for instance, it has become apparent that the vast majority of the genome is transcribed, often in intricate networks of overlapping sense and antisense transcripts, many of which are alternatively spliced [1,4–8].”
The functional role of long non-coding RNA in human carcinomas (2011, background): “Many identified lncRNAs are transcribed by RNA polymerase II (RNA pol II) and are polyadenylated, but this is not a fast rule [47,48].”
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. (2007, background): “2002; Bertone et al. 2004; Cawley et al. 2004; Cheng et al. 2005) reveals that much of this dark matter is transcribed, both within the introns and untranslated regions of protein-coding genes, and within a set of long, apparently noncoding, transcripts.”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Experiments with genome-wide tiling arrays show evidence for small amounts of transcript at almost all genes in numerous cell types (Cheng et al., 2005).”
A quantitative atlas of polyadenylation in five mammals (2012, result): “Similar to early reports of widespread transcription (Cheng et al. 2005), it was later shown that by mass the transcriptional origin of most nonribosomal RNA in a cell can be traced to coding exons or pre-mRNAs (van Bakel et al. 2010).”