DNA hypermethylation in tumorigenesis: epigenetics joins genetics.

By S. Baylin, J. Herman. Trends in Genetics, 2000

1,699 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cb583db8fb7abcde3a8d12b68add55a26220e2ef

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In Molecular Biology

Citations in the corpus

A gene hypermethylation profile of human cancer. (2001, background): “The growing list of genes inactivated by promoter region hypermethylation provides an opportunity to examine the patterns of inactivation of such genes among different tumors (3, 4 ). Recently, a global pattern of methylation events in tumors using restriction landmark genomic scanning was reported”
High-throughput DNA methylation profiling using universal bead arrays. (2006, background): “Changes in DNA methylation are recognized as one of the most common forms of molecular alteration in human neoplasia (Baylin and Herman 2000; Balmain et al. 2003; Feinberg and Tycko 2004).”
Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. (2002, neutral): “In wild-type WS, the resulting cers [10].”
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation (2001, background): “Aberrant hypermethylation also causes transcriptional silencing of tumor-suppressor genes in human tumors, which has led to the proposal that DNA methyltransferases might be good targets for anti-cancer pharmaceutical”
Emerging molecular markers of cancer (2002, background): “CpG ISLANDS in gene-promoter regions are methylated as part of gene regulatio”
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. (2001, background): “, can exhibit this change in non-familial cancers and the selective advantage for loss of gene function is very clear in several ways (1).”
The fundamental role of epigenetic events in cancer (2002, background): “In cancer, however, the hypermethylation of these promoter regions is now the most well-categorized epigenetic change to occur in tumours; it is found in virtually every type of human neoplasm and is associated with the inappropriate transcriptional silencing of gene”
Genomic alterations in cultured human embryonic stem cells (2005, background): “Aberrant methylation of the 5′-end gene promoter regions associated with gene silencing is an epigenetic phenomenon observed in almost all human cancer”
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles (2012, background): “Differential methylation patterns have been previously described in malignancies [27-29] and can be used to differentiate cancer and normal cells [30].”