Genomic alterations in cultured human embryonic stem cells

By A. Maitra, Dan E. Arking, N. Shivapurkar, Morna A Ikeda, V. Stastny, Keyaunoosh Kassauei, G. Sui, David J. Cutler, Y. Liu, Sandii N. Brimble and 14 more. Nature Genetics, 2005

648 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7c1b316daf3aabe5d995b94cc1b0bf9ff5164f1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Matrix elasticity directs stem cell lineage specification. (2006, background): “Importantly, transcriptional profiles of early versus late MSCs (up to passage 12) do not differ significantly (Table S1), even though population expansion has been suggested by others to dramatically alter MSCs (Maitra et al., 2005).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Importantly the absence of replicative senescence is not due to acquisition of genotypic abnormalities in culture as hES cells grown continuously in culture show a normal karyotype and have stable genomes (Maitra et al., 2005).”
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo (2007, background): “, though a few reports have used array-based comparative genomic hybridization (CGH) and single-nucleotide polymorphism (SNP) technique”
Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture (2011, neutral): “Human embryonic stem cell (hESC) lines have been shown to become aneuploid in culture (Baker et al., 2007; Draper et al., 2004; Imreh et al., 2006; Maitra et al., 2005; Mitalipova et al., 2005), and the most frequent changes, trisomies of chromosomes 12 and 17, are also characteristic of malignant…”