A gene hypermethylation profile of human cancer.

By Manel Esteller, P. Corn, S. Baylin, J. Herman. Cancer Research, 2001

2,164 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ac5ea7102ec637690014716104946fe79a29c195

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Citations in the corpus

DNA methylation in cancer: too much, but also too little (2002, background): “Cancer-associated hypermethylation was found in most tumors of a given type in at least a few of these CpG islands (Esteller et al., 2001).”
Epigenetic gene silencing in cancer: the DNA hypermethylome. (2007, background): “Another conclusion is that there is a clear gradient in the distribution of tumors with different degrees of CpG island methylation (55,56).”
Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. (2002, background): “An equal number of intriguing underexpressed genes were identified by meta-analysis including SPARCL1, a candidate tumor suppressor gene (15), and TIMP3, an inhibitor of metalloproteinases that is silenced by methylation in cancers (16), among others.”
5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (2002, background): “At least one CpG island was methylated in 80% or more of samples for each tumor type (Esteller et al., 2001).”
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer (2002, background): “5 uk AA457731 SNARE protein YKT6 6 uk AA419251 interferon induced transmembrane protein 1 (9-27) IFITM1 11 uk N48178 KIAA0403 protein 6 uk AA027147 hypothetical protein MGC3040 3 uk H18646 hypothetical protein FLJ10697 10 uk AA013268 Homo sapiens mRNA containing (CAG)4 repeat, clone CZ-CAG-7 UK uk A”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “A CpG island hypermethylation profile of human primary tumors has emerged, which shows that the CpG island hypermethylation profiles of tumor-suppressor genes are specific to the cancer type (Costello et al., 2000; Esteller et al., 2001a).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “…DNA hypomethylation is sufficient to induce aggressive T-cell lymphomas with a high frequency of chromosome 15 trisomy (Eden et al., 2003; Gaudet et al., 2003), whereas tumor suppressor genes are usually silenced by site-specific DNA hypermethylation at their promoters (Esteller et al., 2001).”
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours (2002, background): “Nowadays, it is recognized that aberrant methylation of APC is a common lesion in other neoplasms of the aerodigestive tract [17] and that E-cadherin promoter hypermethylation is relevant for the cancer biology of breast and other tumour types [9,18].”
The regulation of INK4/ARF in cancer and aging. (2006, unknown): “Finally, p16 INK4a was one of the first genes noted to be silenced epigenetically in human cancers, and silencing through promoter methylation is well described at high frequency in numerous types of human cancers (Esteller et al., 2001).”