Toll‐like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL‐12

By A. Krug, A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. Krieg and 1 more. 2001

417 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/cb4ecdba33df18128e6f5485c0c22f2b797e89af

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In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. O. Takeuchi
5. K. Takeda
6. T. Mogensen
7. T. Kaisho
8. Yong‐jun Liu

Citations in the corpus

• Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002, background): “Of the ten TLR family members, only pDC2s express TLR7 and TLR”
• Plasmacytoid dendritic cells in immunity (2004, background): “The production of IL-12 by human pDCs is controversial, but cells preincubated with IL-3 and then stimulated with CpG oligonucleotides and CD40L are efficient producers of IL-12 (p70 plus p40) while downregulating their ability to produce type I interfero”
• Toll-like receptor control of the adaptive immune responses (2004, background): “In some studies, TLR7 expression was detected on both pDCs and mDC”
• Dendritic cell immunotherapy: mapping the way (2004, background): “Although blood DCs may not require extensive culture, they must be activated through molecularly defined triggers of DC activation, such as TLRs or CD40 ligand, before reinfusio”