Neurodegenerative diseases and oxidative stress

By K. Barnham, Colin L. Masters, Ashley I. Bush. Nature reviews. Drug discovery, 2004

3,753 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/cab0625d89ff33a11c55d6b92591e7e73c852579

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. K. Davies
2. O. Maier
3. H. Forman
4. K. Rahman
5. Roman Fischer
6. Barry Halliwell
7. S. Yamanaka
8. Hongqiao Zhang

In Physiology

1. Kazutoshi Takahashi
2. S. Yamanaka
3. K. Okita
4. K. Davies
5. O. Maier
6. H. Forman
7. K. Rahman
8. Roman Fischer

Citations in the corpus

• Oxidative stress response and Nrf2 signaling in aging. (2015, positive): “Indeed, oxidative stress has been implicated in various pathologies including cardiovascular and neurodegenerative diseases, cancers, diabetes, and cataract, most of which are age-related [1-4].”
• The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer (2005, background): “The highly reactive OH radical is able to induce cell death through initiating a series of chemical reactions with many significant biomolecules, resulting in DNA oxidation, mitochondrial damage, and the peroxidation of membrane lipids (Bergeron et al., 2003c; Barnham et al., 2004).”
• Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. (2007, neutral): “Increased oxidative stress (Mecocci et al., 1994; de la Torre and Stefano, 2000; Emerit et al., 2004) ; 6.”
• On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death (2017, neutral): “The accumulation of lipid hydroperoxides (LOOH) has long been implicated in cell death and dysfunction, leading to aging, 1,2 the onset and progression of degenerative disease, 3,4 and cancer.”
• Metals, oxidative stress and neurodegenerative disorders (2010, neutral): “Ab is a peptide of 39–43 amino acids that appear to be the main constituent of amyloid plaques in the brains of Alzheimer’s disease (AD) patients [1–5].”
• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options (2009, background): “Oxidative stress and free radical generation catalyzed by redox metals have been shown to play pivotal role in regulating redox reactions in vivo contributing RNS and ROS, main culprits in neurodegeneration [42].”
• Studies on free radicals, antioxidants, and co-factors (2007, background): “Since free radicals are implicated in the pathogenesis of neurodegenerative diseases (Emerit et al 2004), the role of Clinical Interventions in Aging 2007:2(2)228 antioxidants in their prevention has been gaining popularity.”