Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

By Yong Zhang, Scott J Goldman, Rebecca Baerga, Yun Zhao, M. Komatsu, Shengkan Jin. Proceedings of the National Academy of Sciences of the United States of America, 2009

653 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/f6f8ff89041f16169f991592e5c7a3aa567ca983

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Beth Levine
2. Douglas R. Green
3. Alec C. Kimmelman
4. A. Cuervo
5. R. Youle
6. S. Jin
7. Rajat Singh
8. N. Mizushima

In Physiology

1. Alec C. Kimmelman
2. Douglas R. Green
3. Beth Levine
4. R. Youle
5. A. Cuervo
6. Lewis C. Cantley
7. J. Asara
8. Rajat Singh

Citations in the corpus

• To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “Reduction in mitochondrial number may also contribute to the role of core autophagy genes, such as Atg7, in white adipocyte differentiation (Zhang et al., 2009).”
• PINK1- and Parkin-mediated mitophagy at a glance (2012, background): “In addition to quality control, mitophagy occurs to regulate mitochondrial number (Zhang et al., 2009b) and eliminate mitochondria during the development of specialized cells or tissues such as reticulocytes (Kundu et al., 2008; Mortensen et al., 2010; Zhang et al., 2009a).”
• Autophagy in the Cellular Energetic Balance (2011, positive): “The function of macroautophagy in the adipose tissue, an organ committed to fat storage, deserves separate mention, since autophagy has been shown to regulate adipose tissue development by modulating adipocyte differentiation (Singh et al., 2009b; Zhang et al., 2009).”
• Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase (2011, positive): “Given that autophagy is required for LD genesis and lipid storage in adipose tissue (Baerga et al., 2009; Singh et al., 2009b; Zhang et al., 2009), along with additional findings that the Atg conjugation system is involved in LD formation in hepatocytes and cardiomyocytes (Shibata et al., 2009), we…”
• Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy (2018, result): “While the decrease in lipid content observed in the ppk-2 mutant animals is opposite of what is seen in the PI5P4K deleted livers of nutrient starved mice, this finding is consistent with models of defective autophagy in non-hepatic tissues (Singh et al., 2009b; (Zhang et al., 2009).”