Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain

By R. Faulkner, M. Jang, Xiao-Bo Liu, Xin Duan, Kurt Sailor, J. Kim, S. Ge, Edward G. Jones, Guo-li Ming, Hongjun Song and 1 more. 2008

222 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “…et al., 2008; Ge et al., 2006), followed by GABAergic synaptic inputs, and finally glutamatergic synaptic inputs (Espó sito et al., 2005; Ge et al., 2006; Overstreet-Wadiche et al., 2006b) and mossy fiber synaptic outputs to hilar and CA3 neurons (Faulkner et al., 2008; Toni et al., 2008).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “In this period, axonal terminals of new DGCs begin to contact interneurons in the hilar region as well as dendritic shafts of CA3 pyramidal cells (Faulkner et al., 2008; Ide et al., 2008; Toni et al., 2008).”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “During adult hippocampal neurogenesis, immature DGCs have unique characteristics within a few weeks after birth, including their morphogenesis and synaptogenesis (Espósito et al., 2005; Ge et al., 2006; Zhao et al., 2006; Toni et al., 2007, 2008; Faulkner et al., 2008), their unique electrophysiolog”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Axonal projections to CA3 are detectable within 2 weeks [35, 36], but appear immature and are targeted to dendritic shafts of CA3 pyramidal neurons rather than to the thorny excrescences where mature DGCs send their boutons [35, 36].”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “While axons of young adult-generated granule cells do form functional mossy fiber boutons onto CA3 pyramidal cells from an early developmental stage, these specialized synapses are not fully mature until after the adult-born neurons are around 8 weeks old (Faulkner et al., 2008; Toni et al., 2008), ”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, unknown): “…developed a specific shRNA against mouse Disc1 (DISC1-shRNA) and confirmed its efficacy and specificity in knocking down endogenous DISC1 in hippocampal neurons in vitro (see Figure S1 in the Supplemental Data) (Faulkner et al., 2008) and in dentate granule cells in vivo (Duan et al., 2007).”