Regulation of JAK–STAT signalling in the immune system

By K. Shuai, Bin Liu. Nature reviews. Immunology, 2003

1,455 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ca2fd97e57a97ab3165cfbc6bc3de97c6e9f3299

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. O’Shea
2. Fang Zhou

In Immunology

1. J. O’Shea
2. Y. Kanno
3. A. Laurence
4. P. Murray
5. E. Shevach
6. Fang Zhou
7. Alexander Y. Rudensky
8. Shimon Sakaguchi

In Oncology

1. J. O’Shea
2. A. Laurence
3. Y. Kanno
4. E. Shevach
5. P. Murray
6. Garry P. Nolan
7. Peter O. Krutzik
8. Fang Zhou

Citations in the corpus

• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “CIS deficient mice had no impaired function of the immune system [33].”
• Single cell profiling of potentiated phospho-protein networks in cancer cells. (2004, methodology): “…lymphoma cell line U-937 were from pathway maps were drawn based on multiple sources (McCubrey et al., 2000; Rane and Reddy, 2002; Shuai and Liu, 2003; StirewaltAmerican Type Culture Collection (www.atcc.org) and cultured in RPMI medium (Invitrogen, Carlsbad, California) 10% Fetal Calf and…”
• Cytokine signaling modules in inflammatory responses. (2008, background): “With seven members in all (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), these DNA-binding proteins provide a rapid membrane to nucleus mechanism for regulation of gene expression (Shuai and Liu, 2003).”
• Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation (2009, background): “Moreover, protein tyrosine phosphatases (PTPs) shp1 and shp-2 can also lead to the dephosphorylation of receptors and JAKs then inhibit IFN-γ signaling [45].”
• Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550) (2011, background): “Activated STATs dimerize, translocate to the nucleus, and regulate the expression of numerous genes (4).”
• Nonredundant roles for Stat5a/b in directly regulating Foxp3. (2007, methodology): “We therefore approached this problem in two ways: (1) stem cell transplantation using Stat5 / precursors; and (2) tissue-specific deletion of Stat5 using transgenic expression of Cre.”