Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits

By J. Szabadics, Csaba Varga, G. Molnár, Szabolcs Oláh, P. Barzó, G. Tamás. Science, 2006

606 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c9f82456345afa27c11ae83ae355cffe9956f457

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Citations in the corpus

Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. (2007, background): “The neocortical microcircuit is characterized by a high degree of synaptic recurrence, in which excitatory, inhibitory, feed-forward, and feedback pathways are interweaved (Douglas and Martin, 1990; Markram et al., 2004; Miles, 1990; Szabadics et al., 2006; Thomson et al., 2002).”
Cation-chloride cotransporters and neuronal function. (2009, methodology): “…of mature neurons, and spatially distinct expression patterns can result in steady-state chloride gradients and compartmentalization of EGABA-A within an individual neuron (e.g., Duebel et al., 2006; Gavrikov et al., 2003; Khirug et al., 2008; Price and Trussell, 2006; Szabadics et al., 2006).”
Pyramidal neurons: dendritic structure and synaptic integration (2008, background): “A surprising discovery is that axonally targeted, GABAergic chandelier cells might not be inhibitor”
Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function (2014, background): “This distinction is particularly important because basket cells have inhibitory effects on their postsynaptic target cells, whereas axo-axonic cells may be excitatory (134).”
Three Groups of Interneurons Account for Nearly 100% of Neocortical GABAergic Neurons (2011, background): “It was recently shown that postsynaptic responses to GABA release from these neurons are depolarizing because of changes in Cl concentration, and hence the reversal potential of GABAA receptors, at the pyramidal cell AIS, the target of chandelier cell axons, and may in fact be excitatory (Szabadics ”
GABAergic interneurons in the neocortex: From cellular properties to circuits (2016, positive): “Chandelier cells have recently generated additional attention as a result of the discovery that in neocortex, GABAergic synapses in the axon initial segment have a depolarized reversal potential compared to those innervating the somatic domain due to a higher intracellular chloride concentration at ”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “In a few cases, we had no morphological reconstructions for rare m-types known to be present in the microcircuitry (L5_BP, L5_ChC, L6_NGC; Oláh et al., 2007; Szabadics et al., 2006).”