Three Groups of Interneurons Account for Nearly 100% of Neocortical GABAergic Neurons

By B. Rudy, G. Fishell, Soohyun Lee, Jens Hjerling-Leffler. Developmental Neurobiology, 2011

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An understanding of the diversity of cortical GABAergic interneurons is critical to understand the function of the cerebral cortex. Recent data suggest that neurons expressing three markers, the Ca2+‐binding protein parvalbumin (PV), the neuropeptide somatostatin (SST), and the ionotropic serotonin receptor 5HT3a (5HT3aR) account for nearly 100% of neocortical interneurons. Interneurons expressing each of these markers have a different embryological origin. Each group includes several types of interneurons that differ in morphological and electrophysiological properties and likely have different functions in the cortical circuit. The PV group accounts for ∼40% of GABAergic neurons and includes fast spiking basket cells and chandelier cells. The SST group, which represents ∼30% of GABAergic neurons, includes the Martinotti cells and a set of neurons that specifically target layerIV. The 5HT3aR group, which also accounts for ∼30% of the total interneuronal population, is heterogeneous and includes all of the neurons that express the neuropeptide VIP, as well as an equally numerous subgroup of neurons that do not express VIP and includes neurogliaform cells. The universal modulation of these neurons by serotonin and acetylcholine via ionotropic receptors suggests that they might be involved in shaping cortical circuits during specific brain states andbehavioral contexts. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 45–61, 2011

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de3823ce17d5c3556611ebc9175ab003491e6061

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Citations in the corpus

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain (2015, background): “The remaining 15%–30% are inhibitory neurons, with approximately 40% expressing PV and 12% expressing VIP (Gelman and Marı́n, 2010; Rudy et al., 2011).”
Plasticity during Sleep Is Linked to Specific Regulation of Cortical Circuit Activity (2017, background): “Although there is a great variety of interneurons in the cortex, these cells represent the great majority of such cells, with PV+ interneurons constituting ∼40% and SOM+ interneurons constituting∼30% of all cortical interneurons (Douglas and Martin, 2004; Markram et al., 2004; Rudy et al., 2011).”
Gamma-band synchronization in the neocortex: novel analysis methods and their application to sensory and motivational systems (2013, methodology): “Together with PV+ cells, SOM+ cells account for approximately 70% of GABAergic cells across rodent S1 layers (Rudy et al., 2011).”
A cortical circuit for gain control by behavioral state (2014, background): “One interesting feature of VIP neurons is that they express serotonin receptor 5HT3a receptor (Lee et al., 2010; Rudy et al., 2011).”
Adult Mouse Cortical Cell Taxonomy by Single Cell Transcriptomics (2016, neutral): “9), this type most likely corresponds to Nos1 Type I neurons 28 , which are enriched in L5 and 6 (ref.”
Parallel processing by cortical inhibition enables context-dependent behavior (2016, neutral): “It may be a general property of developed cortical circuits in the auditory system 20,24,26 and other sensory modalities 23,35 .”