Pyramidal neurons: dendritic structure and synaptic integration

By Nelson Spruston. 2008

1,732 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Active properties of neocortical pyramidal neuron dendrites. (2013, background): “…f(top-down, local, other inputs; bAPs) g(bottom-up, local, other inputs; Ca2+ spikes) B A C B Larkum et al. (2001) Trunk plus obliques Basal y y g Spruston (2008) Distal apical thin branches Perisomatic thin branches Häuser & Mel (2003)Poirazi et al. (1993) 2-layer model 3-layer modelc a…”
Spinogenesis and Pruning Scales across Functional Hierarchies (2009, background): “These specializations in neuron structure are believed to endow different biophysical properties and patterns of connectivity, thus providing specialized substrates for different behavioral complexities (Jacobs and Scheibel, 2002; Chklovskii et al., 2004; Elston, 2007; Spruston, 2008).”
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs (2014, background): “These large excitatory neurons are the primary source of output from a cortical region, projecting to hierarchically subordinate cortical and subcortical regions (Spruston, 2008).”
Dendritic cortical microcircuits approximate the backpropagation algorithm (2018, background): “…bottom-up and top-down synapses converging onto separate dendritic compartments (basal and distal dendrites, respectively), a ﬁrst approximation in line with experimental observations (Spruston, 2008) and reﬂecting the preferred connectivity patterns of cortico-cortical projections (Larkum, 2013).”
Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells (2016, neutral): “Passive Electrical Properties of GoCs If GJ strength does not depend on the dendritic location, how does the dendritic location of GJs affect the GJPs recorded at the soma? Passive cable parameters, such as specific membrane resistivity (Rm), specific axial resistivity (Ra), and specific membrane ca”
Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex (2015, background): “The synapses on the proximal dendrites (typically several hundred) have a relatively large effect at the soma and therefore are best situated to define the basic receptive field response of the neuron (Spruston, 2008).”
Branching out: mechanisms of dendritic arborization (2010, background): “Second, the branching pattern and density of dendrites must be suitable for sampling and processing the signals that converge onto the dendritic fiel”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “Inhibitory types are mostly distinguished by axonal features and excitatory types by dendritic features (for reviews, see Markram et al., 2004; Ramaswamy and Markram, 2015; Spruston, 2008).”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “, 1984) or for direct induction of action potentials (Spruston, 2008).”
Interaction of feedforward and feedback streams in visual cortex in a firing-rate model of columnar computations (2014, background): “Evidence suggests that such inhibitory mechanisms influence the more distal sites of pyramidal cells (Callaway, 1998, 2004; Spruston, 2008).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, neutral): “…neurons across various brain areas (London & Häusser, 2005; Papoutsi, Kastellakis, Psarrou, Anastasakis, & Poirazi, 2014; Poirazi, Brannon, & Mel, 2003; Sidiropoulou, Pissadaki, & Poirazi, 2006; Silver, 2010; Spruston, 2008), their role in pattern separation is just starting to be addressed.”
GABAergic interneurons in the neocortex: From cellular properties to circuits (2016, neutral): “They can also control Cadependent biochemical reactions and hence influence plasticity (Spruston, 2008).”
Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons (2016, background): “Their apical and basal dendrites often receive synaptic inputs that originate from different pathways [15].”