S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

By Z. Gu, M. Kaul, B. Yan, S. Kridel, Jiankun Cui, A. Strongin, Jeffrey W. Smith, R. Liddington, S. Lipton. Science, 2002

958 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c9c66d959a5d7143cff193c026fb291a64ae005b

How researchers see this paper

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In Cancer Research

1. Gillian Murphy
2. Hideaki Nagase
3. R. Visse
4. P. E. Van den Steen
5. J. Vandooren
6. G. Opdenakker
7. E. Koivunen
8. M. Björklund

In Immunology

1. Francis G. Spinale
2. A. Newby

In Oncology

1. Hideaki Nagase
2. Gillian Murphy
3. R. Visse
4. E. Koivunen
5. M. Björklund
6. Francis G. Spinale
7. G. Opdenakker
8. P. E. Van den Steen

Citations in the corpus

• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. (2007, background): “In addition to the classical means of pro-MMP activation, posttranslational modification of pro-MMPs by oxidative stress can also yield an active enzyme (116, 117, 143, 242, 481, 529, 540).”
• Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (2007, background): “In 2002, it was shown that matrix metalloproteinase 9 (MMP9), which causes neuronal apoptosis, is S -nitrosylated by NO that is derived from the endogenous nitrosothiol S -nitrosocystein”
• Excitotoxicity and stroke: identifying novel targets for neuroprotection. (2014, positive): “In both cases, the excitotoxic damage can be prevented by nNOS gene-knockout or MMP inhibition (Gu et al., 2002; Manabe et al., 2005).”
• Gelatinase-mediated migration and invasion of cancer cells. (2005, background): “The proMMP-2 has also been crystallized with the tissue inhibitor of matrix metalloproteinase (TIMP)-2 (Morgunova et al., 2002).”
• Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade (2013, background): “Examples include oxidation (Meli et al., 2003; Paquette et al., 2003), S-nitrosylation (Gu et al., 2002) or S-glutathiolation (Okamoto et al., 2001).”
• The physiology and pathophysiology of nitric oxide in the brain. (2005, background): “Additionally, S-nitrosylation is also involved in the pathological process of activating matrix metalloproteases, e.g., in stroke and neurodegenerative diseases (Gu et al., 2002; Chung et al., 2004).”
• Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons (2006, methodology): “Mice were subjected to 2h of ischemia using middle cerebral artery occlusion (MCAO), followed by a 3h reper- fusion protocol (Gu et al, 2002).”
• Control of matrix metalloproteinase catalytic activity. (2007, background): “To date, the only in vivo evidence we are aware of is in ischemic mouse brains, where activation of proMMP-9 requires s-nitrosylation of the pro-domain (Gu et al., 2002).”