Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

By V. Calabrese, C. Mancuso, M. Calvani, E. Rizzarelli, D. Allan, Butterfield, Anna Maria, Giuffrida Stella. Nature Reviews Neuroscience, 2007

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Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “, 1993), although these molecules also mediate neuroprotective properties (Calabrese et al., 2007).”
Astrocyte crosstalk in CNS inflammation (2020, background): “, 2019), which shows detrimental effects on neurons when in excess (Calabrese et al., 2007).”
The role of nitric oxide in pre-synaptic plasticity and homeostasis (2013, background): “…described its role in retrograde signaling (Brenman and Bredt, 1997), cellular function (Garthwaite, 2008), synaptic plasticity (Holscher, 1997), development (Contestabile, 2000), excitotoxicity (Calabrese et al., 2007), blood flow (Gordon et al., 2007) and mental health (Steinert et al., 2010).”
Concepts of neural nitric oxide-mediated transmission (2008, background): “, 2006), and neuropathology and ⁄ or neuroprotection (Dawson & Dawson, 1998; Contestabile et al., 2003; Keynes & Garthwaite, 2004; Duncan & Heales, 2005; Blokland et al., 2006; Zhang et al., 2006a; Calabrese et al., 2007).”
Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. (2009, neutral): “nNOS and eNOS are constitutively expressed and their activities are calcium-dependent, whereas the activity of iNOS is fully activated at basal intracellular calcium concentration, so its activity is calcium-independent [5].”