The MEK/ERK cascade: from signaling specificity to diverse functions.

By Yoav D. Shaul, R. Seger. Biochimica et Biophysica Acta, 2007

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ERK/MAPK signalling pathway and tumorigenesis (2020, background): “These regulatory factors affect bispecific phosphatases (7‑10), scaffold proteins (11-14), signal duration and intensity (15), and the dynamic subcellular localization of cascade components (16,17).”
MAP kinase pathways. (2012, background): “2) responds primarily to growth factors and mitogens to induce cell growth and differentiation (McKay and Morrison 2007; Shaul and Seger 2007).”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “These distinct speci ﬁ cities may be mediated by spatio-temporal differences, interaction with distinct scaffold proteins, distinct interaction af ﬁ nities with various substrates, and regulation by additional nuclear components [1].”
ERK1/2 MAP kinases: structure, function, and regulation. (2012, neutral): “[11,37]).”
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer (2018, background): “which are transcription factors that regulate the expression of genes involved in mitogenic signaling (McKay and Morrison 2007; Shaul and Seger 2007).”