Signalling ballet in space and time

By Boris N. Kholodenko, John Hancock, Walter Kolch. Nature reviews. Molecular cell biology, 2010

626 citations recorded by the source corpus.

Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries that involve transcriptional feedback. They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e2f9200d298246eb5c6479d810bf52226982987f

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Citations in the corpus

Revitalizing membrane rafts: new tools and insights (2010, background): “The first state is represented by dynamic nanoscale assemblies that associate and dissociate on a subsecond timescal”
Using graph theory to analyze biological networks (2011, background): “These are mainly metabolic, signal transduction or regulatory networks [34].”
Studying and modelling dynamic biological processes using time-series gene expression data (2012, background): “As discussed in recent reviews 93,94 , considering the dynamic behaviour of signalling networks is vital for understanding their biological properties (such as the specificity of different responses), and improvements in experimental technology have enabled the quantification of signalling network…”
Encoding and Decoding Cellular Information through Signaling Dynamics (2013, positive): “Additional studies have shown how dynamics play a role in spatially distributed intracellular networks (Kholodenko et al., 2010 and references therein).”
Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “Readers interested in broadening the picture are referred to two recent review”