Actin dynamics control SRF activity by regulation of its coactivator MAL.

By F. Miralles, G. Posern, A. Zaromytidou, R. Treisman. Cell, 2003

1,373 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c981417333594bc0dec0d7d907b81b25b0b332a3

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Citations in the corpus

The myofibroblast: paradigm for a mechanically active cell. (2010, background): “The molecular basis of G-actin binding to MRTF/MAL is beginning to be understood (Mouilleron et al., 2008) but is presently unknown whether the actin isoform-specific N-terminus has any relevance for this interaction.”
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. (2009, background): “Among these is the actin-dependent SRF coactivator MRTF-B ( Miralles et al. 2003; Kuwahara et al. 2005) and Add3, which caps the”
Role of YAP/TAZ in mechanotransduction (2011, background): “Interestingly, this recapitulates aspects of MAL/SRF regulation 13 , but also entails profound differences: YAP/TAZ activity requires stress fibres and cyto-skeletal tension induced by ECM stiffness and cell spreading, but is not directly regulated by G-actin levels.”
Linking actin dynamics and gene transcription to drive cellular motile functions (2010, neutral): “Subsequent identification of G-actin-regulated nucleus–cytoplasm shuttling of the SRF cofactors, MRTFs, revealed for the first time a direct mechanism enabling cytoplasmic G-actin to control nuclear transcriptional activit”
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression (2004, background): “2a ), suggesting that these cofactors interact with the same region of SRF as has been observed for the myocardin-related transcription factor MA”
Rho GTPases: biochemistry and biology. (2005, background): “Scaffold proteins play a major role in controlling the activation and specificity of MAP kinase pathways in vivo and, interestingly, at least three Rho GTPase targets, POSH, CNK, and MEKK1, act as scaffold proteins (Morrison & Davis 2003).”
Mechanotransduction in development: a growing role for contractility (2009, background): “F-actin dynamics regulate the activity of the transcription factor serum response factor ( SRF ) and its cofactor MAL (also known as MKL1”
Actin stress fibers – assembly, dynamics and biological roles (2012, background): “In addition to its direct effects on the actin cytoskeleton, RhoA signaling regulates the transcription of several genes that encode cytoskeletal proteins through myocardin-related transcription factor (MAL, also known as MKL1 and MRTF-A) and serum response factor (SRF) pathway, and thus also contro”
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. (2009, background): “SRF-dependent gene transcription is controlled at various posttranscriptional levels, including — among others — differential splicing and phosphorylation– and RhoA/Rho kinase–dependent (ROK-dependent) SRF nuclear translocation and/or activation (reviewed in ref.”