Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.
By M. Battaglia, A. Stabilini, M. Roncarolo. Blood, 2005
1,190 citations recorded by the source corpus.
Subfields: Immunology, Microbiology, Oncology
View Paper: https://www.semanticscholar.org/paper/c971a6cc322c1cc4aa4511577031bc8aa63a4c30
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In Immunology
- M. Battaglia
- M. Roncarolo
- Craig B. Thompson
- M. Levings
- Shimon Sakaguchi
- T. Malek
- Erika L. Pearce
- G. Lee
In Oncology
Citations in the corpus
- The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling (2011, background): “Rapamycin can enhance the generation of inducible T reg cell”
- Regulation of Immune Responses by mTOR (2011, background): “T cells lacking mTOR demonstrate increased SMAD3 activation and become Foxp3+ Tregs even under normally activating conditions.”
- Fuel feeds function: energy metabolism and the T-cell response (2005, background): “For example, it was recently reported that the immunosuppressive action of rapamycin in vivo involves the selective accumulation of CD4 + CD25 + regulatory T cells, which can suppress effector T-cell proliferation in vitro and prevent allograft rejection in vivo”
- Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 (2006, methodology): “1%; n 9) from healthy subjects or T1D patients were stained with CFSE (Molecular Probes), as described elsewhere (18), and cultured in 96-well plates (2 10(5)/well) precoated with anti-CD3 (10 g/ml) and with soluble anti-CD28 (1 g/ml) mAbs (BD Biosciences).”
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008, neutral): “TGF is a potent inducer of Foxp3 expression in vitro (14) and in vivo (15–17) and immunosuppressive drugs, such as rapamycin (18–20), act by as yet undefined mechanisms to induce Foxp3 expression (18) or to expand preexisting Treg cells (19, 20).”
- Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions (2014, background): “Indeed, inhibition of glycolysis by rapamycin has been shown to facilitate the generation of murine naturally occurring CD4+CD25+Foxp3+ Tregs in vitro, which were able to prevent allograft rejection in vivo (56), illustrating the link between T cell differentiation, metabolism, and immunity.”
- Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “This drug blocks the expansion of murine effector T cells, while sparing the CD4CD25 Tregs (91).”