The two TORCs and Akt.

By Prashanth T. Bhaskar, N. Hay. Developmental Cell, 2007

847 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c96de6554a916377a36f7cd1afc66808ebb7316a

How researchers see this paper

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In Molecular Biology

1. D. Morrison
2. N. Hay
3. A. Baldwin
4. J. Ting
5. Y. Fouad
6. C. Aanei

Citations in the corpus

• Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis (2008, background): “Most importantly, we showed that rapamycin, which is usually cytostatic, sensitizes cells to ROS-mediated cell death because it also activates Akt via the inhibition of a negative feedback loop (Bhaskar and Hay, 2007; Harrington et al., 2005; Hay, 2005).”
• AMP-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype (2008, neutral): “mTOR is the only critical subunit shared by mTORC1 and mTORC2, and competition for mTOR interaction can occur between the mTORC1 and mTORC2 complexes (48).”
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. (2012, neutral): “…of mammalian target of rapamycin (Raptor), G protein b subunit-like protein (GbL), proline-rich Akt substrate of 40 kDa (PRAS40), and Deptor (Bhaskar and Hay, 2007; Foster and Fingar, 2010). mTORC1 phosphorylation of S6K and 4E-BP is the rate-limiting step in translation, which leads to…”
• The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development (2008, background): “Signaling through this pathway converges on the mTOR complex 1 (TORC1) [15,17] and, strikingly, 14-3-3 binds four different regulators of TORC1 signaling.”
• Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. (2008, background): “mTOR is associated with two complexes (Bhaskar and Hay 2007): the rapamycin-sensitive TORC1 complex that controls S6K phosphorylation, and TORC2 (Hay and Sonenberg 2004), which is the PDK2 activity that controls ser473 phosphorylation of Akt (Sarbassov et al.”
• Redox Regulation of Cell Survival (2008, neutral): “der oxidative stress, although the ubiquitin-activating enzymes (E1) and 26S proteosome are oxidatively inactivated, oxidized proteins may no longer be ubiquitinated and degraded (22).”
• Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “S6K1 is a central player in the TOR signaling cascade, a major regulator of protein expression related to cell growth (Bhaskar and Hay, 2007).”