Ubiquitin is phosphorylated by PINK1 to activate parkin

By Fumika Koyano, K. Okatsu, H. Kosako, Y. Tamura, Etsu Go, M. Kimura, Y. Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, T. Hirokawa and 6 more. Nature, 2014

1,394 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/c8770aa80c63db7640f34724aca017faaa54bbaa

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In Epidemiology

1. I. Slaninová
2. Edward A. Fon
3. Gian-Luca McLelland
4. J. Harper
5. Shireen A. Sarraf
6. Ayumu Sugiura
7. A. Ordureau
8. B. Padman

In Molecular Biology

1. I. Slaninová
2. Steven P. Gygi
3. Mark P. Jedrychowski
4. S. Beausoleil
5. J. Harper
6. J. Wells
7. B. Schulman
8. Shireen A. Sarraf

In Neurology

1. I. Slaninová
2. J. Harper
3. Shireen A. Sarraf
4. Edward A. Fon
5. A. Ordureau
6. B. Padman
7. M. Lazarou
8. Gian-Luca McLelland

Citations in the corpus

• Quantitative proteomics reveal a feed-forward model for mitochondrial PARKIN translocation and UB chain synthesis (2014, positive): “…Translocation and Ubiquitin Chain Synthesis, Molecular Cell (2014), http://dx.doi.org/10.1016/j.molcel.2014.09.007 2014; Kazlauskaite et al., 2014b; Koyano et al., 2014), our results differ from those of Kazlauskaite et al. (2014b) in that they concluded that for p-UB to fully activate PARKIN,…”
• The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of TBK1 activation and recruitment of OPTN and NDP52 to promote mitophagy (2015, background): “…on the mitochondrial outer membrane (MOM), where it promotes phosphorylation of PARKIN on S65 in its N-terminal UB-like domain, as well as the conserved S65 within UB on mitochondria (Kane et al., 2014; Kazlauskaite et al., 2014; Kondapalli et al., 2012; Koyano et al., 2014; Ordureau et al., 2014).”
• Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “Parkin was shown to have a high affinity for pS65-Ub and this drives Parkin recruitment from the cytosol to the OMM [18,20–22].”
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “745).(746) p-S65-Ub antibodies have been used to demonstrate stress-induced activation of PINK1 in various cells including primary human fibroblasts (Fig.”
• Insights in Post-Translational Modifications: Ubiquitin and SUMO (2022, background): “This Ub modification mediates substrate specificity and unlocks the autoinhibition of PARKIN E3 ligase [89].”