Mammalian Heart Renewal by Preexisting Cardiomyocytes
By S. Senyo, M. Steinhauser, Christie L Pizzimenti, Vicky K. Yang, Lei Cai, Mei Wang, Ting-di Wu, J. Guerquin-Kern, C. Lechene, Richard T. Lee. Nature, 2012
1,293 citations recorded by the source corpus.
Although recent studies have revealed that heart cells are generated in adult mammals, the frequency of generation and the source of new heart cells are not yet known. Some studies suggest a high rate of stem cell activity with differentiation of progenitors to cardiomyocytes. Other studies suggest that new cardiomyocytes are born at a very low rate, and that they may be derived from the division of pre-existing cardiomyocytes. Here we show, by combining two different pulse–chase approaches—genetic fate-mapping with stable isotope labelling, and multi-isotope imaging mass spectrometry—that the genesis of cardiomyocytes occurs at a low rate by the division of pre-existing cardiomyocytes during normal ageing, a process that increases adjacent to areas of myocardial injury. We found that cell cycle activity during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid, mononucleate cardiomyocytes. These data reveal pre-existing cardiomyocytes as the dominant source of cardiomyocyte replacement in normal mammalian myocardial homeostasis as well as after myocardial injury.
Subfields: Cancer Research, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/3bcdd7bf4b77ba557bb8e91d0e041afc8c469fa6
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In Molecular Biology
Citations in the corpus
- Cellular and molecular mechanisms of skin wound healing (2024, neutral): “However, this is not the whole story because it seems that full cardiac regeneration in neonatal mice and in adult zebrafish is also linked to the capacity for differentiated cardiomyocytes to proliferate, which largely shuts down in the adult mammalian heart 260,261 .”
- Dynamics of Cell Generation and Turnover in the Human Heart. (2015, background): “…of new cardiomyocytes (Bersell 1566 Cell 161, 1566–1575, June 18, 2015 ª2015 Elsevier Inc. et al., 2009; Ellison et al., 2013; Hsieh et al., 2007; Senyo et al., 2013; Uchida et al., 2013; van Berlo et al., 2014) and the extent of cell generation (Bergmann et al., 2009; Hosoda et al., 2009;…”
- Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction (2015, background): “, Tim Luongo(1), John Elrod(1), Gangjian Qin, PhD.(2), Steven R Houser, PhD.”