Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair

By B. Kühn, F. Monte, R. Hajjar, Yuh-Shin Chang, Djamel Lebeche, S. Arab, M. Keating. Nature Medicine, 2007

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Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, background): “, 2009) and periostin (POSTN) (Kühn et al., 2007), can induce subpopulations of these cardiomyocytes to reenter the cell cycle in vitro.”
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. (2009, neutral): “Microscopy, Cardiomyocyte Volumes and Cross-Sectional Area, and Sarcomere Disassembly Immunofluorescence microscopy and fate tracking in vitro were performed as described elsewhere (Kuhn et al., 2007).”
Cardiomyocyte proliferation contributes to heart growth in young humans (2013, result): “001), which is in agreement with previous reports of cycling mononucleated cardiomyocytes in growing cats (19), rats (20), and mice (21).”
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, methodology): “Recombinant periostin exhibited enhanced tissue distribution and persistence via controlled local delivery from Gelfoam patches in a rat MI model (Kühn et al., 2007).”