Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

By Lindsey J. Macpherson, A. Dubin, M. J. Evans, F. Marr, Peter G. Schultz, B. Cravatt, Ardem Patapoutian. Nature, 2007

1,104 citations recorded by the source corpus.

Subfields: Biochemistry, Complementary and alternative medicine, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/d732fce11d3f98f19fc690a04afb27c18c87e284

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. D. Julius
2. A. Dinkova-Kostova
3. Rui Wang
4. Z. G. Li

In Complementary and alternative medicine

1. D. Julius

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. A. Dubin
4. Jayanti Mathur
5. S. Bevan
6. D. Andersson
7. C. Gentry
8. Sian Moss

Citations in the corpus

• Chemical activation of the mechanotransduction channel Piezo1 (2015, background): “…chemical activation of TRP channels have been crucial to understand the physiological role of these channels and have contributed to mechanistic appreciation of how these ion channels are gated (Jordt and Julius, 2002; Bandell et al., 2006; Macpherson et al., 2007; Cao et al., 2013; Julius, 2013).”
• Exploiting Quorum Sensing To Confuse Bacterial Pathogens (2013, background): “SAR studies found that cinnamaldehyde analogues disrupted, modestly, LuxR’s interaction with the LuxR consensus binding sequence (281); however, mechanisms explaining these effects have not been clear, and the knowledge that cinnamaldehyde is able to covalently modify cysteine residues of various pr”
• Cellular and Molecular Mechanisms of Pain (2009, neutral): “For example, allyl isothiocyanate (from wasabi) or allicin (from garlic) are membrane permeable electrophiles that activate TRPA1 by covalently modifying cysteine residues within the amino-terminal cytoplasmic domain of the channel (Hinman et al., 2006; Macpherson et al., 2007).”
• TRP channels and pain. (2013, background): “Pharmacological and genetic studies have shown that TRPA1 plays an essential role in the nociceptive response to these and other environmental irritants (Bautista et al. 2006, Bessac et al. 2009, Kwan et al. 2006, Macpherson et al. 2007b, McNamara et al. 2007).”
• Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “TRPA1 is activated by a variety of plant-derived and environmental irritants, such as allyl isothiocyanate (AI), cinnamaldehyde (CA), allicin, and acrolein, all of which interact with cysteine residues in the ion channel proteins (384).”
• Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, positive): “These results are consistent with the independent previous reports by two other groups that 4-HNE activates TRPA1 (Macpherson et al., 2007b; Trevisani et al., 2007).”
• Oxidative Stress in Cancer (2020, background): “Within human TRPA1, Cys-414, Cys-421, Cys-621, Cys-641, and Cys-665 contribute to regulation of the channel by electrophiles (Hinman et al., 2006; Macpherson et al., 2007).”