iPS cells produce viable mice through tetraploid complementation

By Xiao-Yang Zhao, Zhuo Lv, Lei Liu, Man Tong, T. Hai, J. Hao, Chang-long Guo, Qing-wen Ma, Liu Wang, F. Zeng and 1 more. Nature, 2009

830 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c749e63cd489604590dd4e90e1dd17cedcdc00a2

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Citations in the corpus

Induced pluripotency: history, mechanisms, and applications. (2010, background): “More recently, rare iPSC lines have been identified that are even capable of generating ‘‘all-iPSC’’ mice upon injection into tetraploid blastocysts (Boland et al. 2009; Kang et al. 2009; Zhao et al. 2009; Stadtfeld et al. 2010b), suggesting that at least some iPSC clones have a developmental potenc”
Control of Embryonic Stem Cell State (2011, background): “A few murine iPSCs have been shown to be capable of generating ‘‘all-iPSC’’ mice and thus have a developmental potency equivalent to ESCs (Boland et al., 2009; Kang et al., 2009; Stadtfeld et al., 2010; Zhao et al., 2009).”
Epigenetic memory in induced pluripotent stem cells (2010, background): “…embryonic germ layers, and when injected into murine blastocysts contribute to all tissues, including the germ line. iPSC from mouse embryo fibroblasts generate “all-iPSC mice” following injection into tetraploid blastocysts 2 , thereby satisfying the most stringent criterion of pluripotency 3 .”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “Murine iPSCs share all defining features with naive mouse ESCs, including expression of pluripotencymarkers, reactivation of both X chromosomes, and the ability to generate chimeras and all-iPSC mice following tetraploid complementation (Boland et al., 2009; Kang et al., 2009; Zhao et al., 2009).”
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder (2016, methodology): “Oocytes and zygotes collection Embryo collection and transfer were performed as previously described (32).”
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. (2010, background): “Mouse iPSCs are similar to ESCs in most aspects and can generate entire individuals after tetraploid complementation (Kang et al., 2009; Okita et al., 2007; Wernig et al., 2007; Zhao et al., 2009).”
The promise of induced pluripotent stem cells in research and therapy (2012, methodology): “This test has been accomplished for only a limited subset of iPS cell”
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, background): “Fully reprogrammed induced pluripotent stem cells (iPSCs) can contribute to the three germ layers and give rise to fertile mice by tetraploid complementation (Okita et al., 2007; Zhao et al., 2009).”