Sleep and synaptic homeostasis: a hypothesis.

By Giulio Tononi, Chiara Cirelli. Brain Research Bulletin, 2003

1,143 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c71da3a19fd30e0ab1c3ed56c28710b7cd253a9f

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In Cognitive Neuroscience

Citations in the corpus

Local sleep and learning (2004, background): “It has been suggested that SWA homeostasis may reflect synaptic changes underlying a cellular need for slee”
Is Sleep Essential? (2008, background): “environment and need to learn, there is a net increase in synaptic strength in many brain areas, in which case sleep would be needed to renormalize such changes [90,91].”
Sleep to Remember (2006, background): “Recently, a synaptic homeostasis hypothesis has been proposed by Tononi and Cirelli (2003, 2006) according to which encoding activity during wakefulness results in a net increase in synaptic strength in many brain circuits.”
Sleep function and synaptic homeostasis. (2006, background): “In brief, the hypothesis is as follows: ( 1 ) Wakefulness is associated with synaptic potentiation in several cortical circuits; (2) Synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) Slow wave activity is associated with synaptic downscaling; (4) Synaptic downsca”
Modeling sleep and wakefulness in the thalamocortical system. (2005, result): “The role of GABA A in the model during waking is consistent with both physiological and theoretical studies (Traub et al. 2003; Whittington et al. 2000).”
The Sleep Slow Oscillation as a Traveling Wave (2004, background): “…along connected pathways during sleep may play a role in spike timing-dependent synaptic plasticity (Abbot and Nelson, 2000; Ermentrout and Kleinfeld, 2001) and lead to synaptic consolidation (Sejnowsky and Destexhe, 2000; Steriade and Timofeev, 2003) or downscaling (Tononi and Cirelli, 2003).”
Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity (2012, neutral): “According to the sleep synaptic homeostasis hypothesis (Tononi and Cirelli, 2003, 2006), SWS results in a general synaptic downscaling because of a strong reduction in gene expression contributing to LTP (Cirelli et al., 2004; Cirelli and Tononi, .”
Drosophila strategies to study psychiatric disorders. (2013, background): “Sleep is proposed to play a role in synaptic homeostasis, where synaptic connections formed during the day are downscaled during sleep [162].”
The Role of Sleep in Cognition and Emotion (2009, background): “In recent years an orthogonal theory of SWS and learning has emerged, one which postulates a role for sleep in regulating the synaptic connectivity of the brain—principally the neocortex (Tononi & Cirelli 2003, 2006).”
Sleep and synaptic renormalization: a computational study. (2010, result): “705 A progressive increase in synaptic strength in the course of wakefulness could be the result of an 706 overall bias in favor of potentiation during learning, consistent with some theoretical considerations 707 (Tononi & Cirelli 2003).”
Sleep Is for Forgetting (2017, methodology): “Therefore, the type of forgetting we will discuss here is also not the global synaptic weight downscaling of the synaptic homeostasis hypothesis (SHY) (Tononi and Cirelli, 2003), although evidence from excellent experiments used to support the idea of sleep for synaptic homeostasis will be used to m”
How (and why) the immune system makes us sleep (2009, neutral): “More than half a century of intense investigation has yet to provide an unequivocal answer to the question, 'Why do we sleep?' Nonetheless, we are beginning to understand the contribution of sleep to fundamental brain processe”