Sleep function and synaptic homeostasis.

By Giulio Tononi, Chiara Cirelli. Sleep Medicine Reviews, 2006

2,155 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/f15be3dfc68f65090e9a81def42ccfc066bcf558

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

The two‐process model of sleep regulation: a reappraisal (2016, background): “Tononi and Cirelli have proposed the synaptic homeostasis hypothesis of sleep regulation (Tononi and Cirelli, 2006, 2014).”
Sleep-dependent consolidation of auditory discrimination learning in adult starlings (2010, background): “Synaptic markers were also found to decrease during sleep (Gilestro et al., 2009), which may represent a process of synaptic downscaling that is hypothesized to improve the signal-to-noise ratio of newly formed memory traces (Tononi and Cirelli, 2006).”
How Memory Replay in Sleep Boosts Creative Problem-Solving (2018, background): “When this strengthening of the overlap is combined with memory degradation, the abstracted representation of regularities may remain, even if memory for each individual birthday party, or details about that party, is lost via general forgetting, synaptic downscaling [20], or targeted depotentiation ”
Network-timing-dependent plasticity (2015, background): “…solution, and may have implications for the mechanisms underlying pathological network states that occur in epilepsy (Trasande and Ramirez, 2007) as well as the down-scaling of synaptic weights during slow-wave sleep (Massimini and Amzica, 2001; Tononi and Cirelli, 2006; Vyazovskiy et al., 2008).”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “In fact, there is evidence that excitatory synaptic connections in the cortex are overall depressed in sleep and potentiated in wakefulness (1019), suggesting that a primary function of slow-wave sleep is homeostatic regulation of synaptic circuitry (283, 655, 959).”
Daytime Naps, Motor Memory Consolidation and Regionally Specific Sleep Spindles (2007, background): “Pioneering work by Tononi and colleagues has demonstrated that overnight memory enhancements are regulated by homeostatic, regionally specific changes in sleep physiology [23].”
The molecular and systems biology of memory. (2014, positive): “Extending earlier proposals that sleep had evolved to maintain homeostasis (Crick and Mitchison, 1983; Borbély and Achermann, 1999), Tononi and Cirelli (2006) posited that plastic processes during wakefulness result in a net widespread increase in synaptic strength in the brain, and the role of…”
Biologically inspired sleep algorithm for increased generalization and adversarial robustness in deep neural networks (2020, background): “These changes entail both an increase in synaptic weights associated with a speciﬁc task and pruning of synapses involved in other tasks (Gonzalez et al., 2019; Tononi & Cirelli, 2006).”
Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity (2012, neutral): “According to the sleep synaptic homeostasis hypothesis (Tononi and Cirelli, 2003, 2006), SWS results in a general synaptic downscaling because of a strong reduction in gene expression contributing to LTP (Cirelli et al., 2004; Cirelli and Tononi, .”
Auditory closed-loop stimulation of the sleep slow oscillation enhances memory. (2013, background): “Importantly, the SO critically contributes to information processing during sleep: apart from an involvement in synaptic downscaling and homeostasis (Tononi and Cirelli, 2006), SOs play a causal role for the consolidation of memory (Chauvette et al.”