Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity

By Sylvain Chauvette, J. Seigneur, Igor Timofeev. 2012

293 citations recorded by the source corpus.

Summary Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo pre-thalamic electrical stimulation at 1 Hz which itself does not induce immediate potentiation of evoked responses, we investigated how the cortical evoked response was modulated by different states of vigilance. We found that somatosensory evoked potentials during wake were enhanced after a slow-wave sleep episode (with or without stimulation during sleep) as compared to a previous wake episode. In vitro, we determined that this enhancement has a postsynaptic mechanism that is calcium-dependent, requires hyperpolarization periods (slow waves), and requires a co-activation of both AMPA and NMDA receptors. Our results suggest that long-term potentiation occurs during slow-wave sleep supporting its contribution to memory.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Replay in Deep Learning: Current Approaches and Missing Biological Elements (2021, neutral): “In biological networks, normalization and synaptic changes co-occur with replay (Chauvette, Seigneur, & Timofeev, 2012; Tononi & Cirelli, 2014).”
About sleep's role in memory. (2013, neutral): “Recently, Chauvette and colleagues (187) showed in vivo that somatorsensory evoked potentials in cats were enhanced after a short period of SWS (about 5–10 min) compared with the previous wake period.”
Cellular and neurochemical basis of sleep stages in the thalamocortical network (2016, background): “, 1999) and reduces evoked responses (Chauvette et al., 2012).”
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep. (2020, background): “SO firing patterns were found to be supportive for induction of long-term synaptic plastic changes (Chauvette et al. 2012), so”
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, result): “By contrast, a recent study in head-restrained cats saw an increase in the cortical response evoked by medial lemniscus stimulation after sleep (Chauvette et al., 2012).”
Auditory closed-loop stimulation of the sleep slow oscillation enhances memory. (2013, background): “Importantly, the SO critically contributes to information processing during sleep: apart from an involvement in synaptic downscaling and homeostasis (Tononi and Cirelli, 2006), SOs play a causal role for the consolidation of memory (Chauvette et al., 2012; Diekelmann and Born, 2010; Marshall et al.,”
The restless engram: consolidations never end. (2012, background): “This view that REM sleep is acting to complete SWS-induced systems consolidation by promoting synaptic consolidation processes, is however challenged by evidence indicating that the cascade of molecular processes underlying synaptic potentiation and even sprouting of synaptic boutons canalsobe induc”