Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.

By C. Chazaud, Y. Yamanaka, Tony Pawson, Janet Rossant. Developmental Cell, 2006

937 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/c7163467cd225672cd7af90ceaa76a8565647234

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Citations in the corpus

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages (2013, background): “5, and (2) expressed an average fold-change of at least 8 from E3.”
Naive and primed pluripotent states. (2009, background): “Indeed, chimera experiments show that while single ICM cells have a tendency to contribute to only hypoblast or only epiblast, a fraction of cells do contribute to both (Chazaud et al., 2006).”
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009, background): “75), when the hypoblast is thought to be already determined (Chazaud et al., 2006), and cultured with or without inhibitors for 2 days.”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “It may fluctuate in early ICM cells (Chazaud et al., 2006; Dietrich and Hiiragi, 2007) but subsequently is uniformly and exclusively expressed in the nascent epiblast.”
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse (2009, background): “Although it has been shown that visceral endoderm are descendants of the ICM and the primitive endoderm of the blastocyst (Weber et al., 1999; Chazaud et al., 2006; PereaGomez et al., 2007), it remains unknown whether they derive from specific progenitor cells that are set aside early in the ICM or…”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “Consistently, inhibition of MAPK/Erk signaling antagonizes differentiation of the ICM in the mouse blastocyst (Chazaud et al. 2006; Nichols et al. 2009b).”
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. (2007, background): “Interestingly, inner cell mass cells of the blastocyst, from which ES cells are derived, show a similarly heterogeneous expression pattern for Oct4 and Nanog ( Chazaud et al., 2006 ).”
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst (2010, background): “It was recently reported that combined inhibition of FGFR/ERK/GSK3 signaling also blocked PE differentiation (Nichols et al., 2009), similar to the Grb2 mutant phenotype (Chazaud et al., 2006).”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “Fgf4 (ligand), Fgfr2 (receptor), and Grb2 (a downstream effector) null embryos lack PE and/or its postimplantation derivatives (Arman et al., 1998; Chazaud et al., 2006; Feldman et al., 1995).”