Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

By Nimet Maherali, Rupa Sridharan, Wei Xie, J. Utikal, S. Eminli, Katrin Arnold, M. Stadtfeld, Robin Yachechko, J. Tchieu, R. Jaenisch and 2 more. Cell Stem Cell, 2007

1,770 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9f7a1eec207fc472688fe5dd2323138d332cc74f

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Citations in the corpus

Induced pluripotency: history, mechanisms, and applications. (2010, background): “The transition to a pluripotent state is also accompanied by genome-wide remodeling of chromatin modifications, such as DNA and histone tail methylation from a somatic to an ESC-like state (Maherali et al. 2007; Mikkelsen et al. 2008), although the temporal sequence of these changes remains elusive.”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “And, in female cells, genes on the inactive X chromosome are reactivate”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “However it was later proven by Yamanaka’s group, as well as by others, that iPS cells capable of germline transmission could be generated (Maherali et al., 2007; Meissner et al., 2007; Okita et al., 2007; Wernig et al., 2007).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “…and Technology Agency, Kawaguchi 332-0012, Japan 3Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA 4Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan *Correspondence: yamanaka@frontier.kyoto-u.ac.jp DOI 10.1016/j.cell.2007.11.019”
The promise of induced pluripotent stem cells in research and therapy (2012, background): “A crucial event during epigenetic reprogramming is the reactivation of the silent X chromosome, which occurs late in reprogramming and represents a hallmark of ground-state pluripotenc”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “Recent works indicate that Oct4 and Sox2, along with c-Myc and Klf4, are sufficient for reprogramming fibroblasts to induced pluripotent stem cells (iPS), which are functionally similar to ES cells (Maherali et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007).”
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. (2008, background): “…to initiate a reprogramming process that results in the transformation of mouse fibroblasts into embryonic stem (ES)-like cells designated as induced pluripotent stem (iPS) cells (Maherali et al., 2007; Meissner et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007).”
Role of the murine reprogramming factors in the induction of pluripotency (2009, neutral): “Molecularly, reprogramming results in the remodeling of the somatic cell transcription and chromatin programs to the ES-like state, including the reactivation of the somatically silenced X chromosome, demethylation of the Oct4 and Nanog promoter regions, and genome-wide resetting of histone H3 lysin”
A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells (2010, background): “These individuals undergo apparently normal development until 6–18 months of age, followed by impaired motor function, stagnation and then regression of developmental skills, hypotonia, seizures and autistic behavior (Amir et al., 1999).”