A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

By Shiaoching Gong, C. Zheng, M. Doughty, K. Losos, N. Didkovsky, U. Schambra, N. Nowak, A. Joyner, G. Leblanc, M. Hatten and 1 more. Nature, 2003

2,137 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/c713328dc13a846b06612ba17a2bb8f2cae07994

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. Karel Svoboda
2. Liqun Luo
3. Edward M. Callaway
4. Lambda Moses
5. Lior S. Pachter
6. Karl Deisseroth
7. Carl C. H. Petersen

In Molecular Biology

1. R. Malenka
2. Charles R. Gerfen
3. D. Surmeier
4. Karl Deisseroth
5. Edward M. Callaway
6. Liqun Luo
7. Lief Ericsson Fenno
8. Bernardo L. Sabatini

In Neurology

1. Bernardo L. Sabatini
2. N. Tritsch
3. D. Surmeier
4. Charles R. Gerfen
5. R. Malenka
6. C. Lüscher
7. J. Kauer
8. Karel Svoboda

Citations in the corpus

• Locomotor circuits in the mammalian spinal cord. (2006, background): “It is possible such markers will appear as a result of large genetic screening of neuronal markers (Gong et al. 2003, Gray et al. 2004).”
• Modulation of striatal projection systems by dopamine (2011, positive): “The most compelling evidence for this conclusion has come from work with bacterial artificial chromosome (BAC) transgenic mice in which expression of a fluorescent reporter molecule, most commonly enhanced green fluorescent protein (eGFP), is driven by the promoter region of either the D1 or D2 rece”
• Neuronal subtype specification in the cerebral cortex (2007, background): “, the creation of transgenic mouse lines expressing GFP under the control of promoters of lineage- or layer-restricted gene”
• Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “An example of the types of studies that will advance our understanding of the neural circuit adaptations that underlie addiction comes from experiments using BAC transgenic mice in which specific subpopulations of cells can be labeled with fluorescent markers (Gong et al., 2003).”
• Dopaminergic modulation of synaptic transmission in cortex and striatum (2012, background): “…in transgenic mice using bacterial artificial chromosomes (BACs) that express Cre recombinase or fluorescent proteins such as enhanced green fluorescent protein (EGFP) or tdTomato under control of the promoter region for D1 or D2 receptor genes (Ade et al., 2011; Gong et al., 2003, 2007).”
• Application of BACarray for comparative analysis of CNS cell types (2008, methodology): “BACs from Table S1 were modified as described to insert an EGFP-L10a fusion protein into the translation start site of the driver gene (Gong et al., 2002; Gong et al., 2003).”
• Genetic dissection of neural circuits. (2008, positive): “A largescale BAC transgenic project (GENSAT) is providing complementary data on regulatory elements that may restrict gene expression to specific cell types (Gong et al., 2003) (Figure 2H).”
• The origin and specification of cortical interneurons (2006, background): “Lhx6 is expressed in the MGE-derived interneuronal progenitors upon their migration to the cortex (Lavdas et al. 1999; Gong et al. 2003), and its expression is maintained in most PV-expressing and SSTexpressing cortical interneurons in adult mice (Fogarty et al.”