Dopaminergic modulation of synaptic transmission in cortex and striatum
By N. Tritsch, Bernardo L. Sabatini. 2012
726 citations recorded by the source corpus.
Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. For example, release of DA within nucleus accumbens signals reward and rapidly modifies brain function to drive repetition of motor action in search of further reward. The control that DA exerts over behavior is also clear in humans, as mimicry of dopaminergic reward signals underlies addiction to drugs of abuse, whereas death of midbrain dopaminergic neurons causes Parkinson’s disease (PD). In addition, perturbations of DA are implicated in the pathogenesis, or exploited in the treatment of many neuropsychiatric diseases including schizophrenia, obsessive compulsive disorder, and Tourette’s syndrome. Although the precise mechanisms employed by DA to exert its control over behavior are not fully understood, DA is known to regulate many electrical and biochemical aspects of neuronal function including excitability, synaptic transmission, integration and plasticity, protein trafficking and gene transcription. In this review, we discuss the actions of DA on ionic and synaptic signaling in neurons of the prefrontal cortex and striatum, brain areas in which dopaminergic dysfunction is thought to be central to the above-mentioned diseases. We focus on actions of DA on the pre- and postsynaptic terminals and restrict our discussion to studies in which the site of action or the molecular target of DA is clearly identified.
Subfields: Cellular and Molecular Neuroscience, Neurology
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In Cellular and Molecular Neuroscience
- Raphael Cohn
- Ianessa Morantte
- D. Dombeck
- R. McCutcheon
- Viviana Gradinaru
- Jianzhi Zeng
- A. Nimmerjahn
- V. Ruta
In Neurology
Citations in the corpus
- Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “Taken together, these findings indicate that neuromodulation in the mushroom body instructs opposing forms of synaptic plasticity, analogous to the bidirectional tuning of synaptic strength by dopamine in mammalian brain centers (Huang et al., 2004; Shen et al., 2008; Tritsch and Sabatini, 2012).”
- Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “Dopamine shapes circuit function in diverse ways by engaging distinct classes of receptors that couple to different signaling cascades (Tritsch and Sabatini, 2012).”
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, background): “The effects of dopamine in the cortex are distinct to those in the striatum, and only a fraction of cortical pyramidal neurons express dopamine receptors, with cortical interneurons showing proportionally greater expression [178].”
- Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors (2018, methodology): “We selected the target sequences that has (1) the GC content of 45-60%, (2) no nucleotide repeats more than 3, (3) no more than 20 hits when blasted, (4) higher than a ΔG of -9 kcal/mol to avoid self-dimers.”