Modulation of striatal projection systems by dopamine

By Charles R. Gerfen, D. Surmeier. Annual Review of Neuroscience, 2011

1,594 citations recorded by the source corpus.

The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Striatal direct and indirect pathways form the functional backbone of the basal ganglia circuit. Twenty years ago it was proposed that the ability of the striatum to use the rise and fall of dopamine (DA) to control action selection was due to the segregation of D1 and D2 DA receptors in direct and indirect pathway spiny projection neurons. Although this sparked a debate, the evidence accumulated since clearly supports this model. In particular, recent advances in the means of marking neural circuits with optical or molecular reporters has revealed a clear-cut dichotomy between these two cell types at the molecular, anatomical and physiological levels. The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/aba739ee876a58635506c05c0c70f350268508f2

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Citations in the corpus

Dopaminergic modulation of synaptic transmission in cortex and striatum (2012, background): “…pharmacological, and single-cell RT-PCR studies determined that dSPNs express high levels of D1 receptors along with the peptides neurotransmitter substance P and dynorphin, whereas iSPNs express D2 receptors as well as the neurotransmitter enkephalin (Gerfen, 1992; Gerfen and Surmeier, 2011).”
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement (2011, neutral): “…experimental control of neuronal populations that are likely to influence a wide variety of neural and behavioral functions (Changeux, 2010; Surmeier et al., 2009; Shen et al., 2008; Gerfen and Surmeier, 2011; Nader and LeDoux, 1999; Montague et al., 2004) in this important animal system.”
Dopamine release in the basal ganglia (2011, background): “A role for DA in motor behavior is well-established: DA regulates neuronal output (e.g., Gerfen and Surmeier, 2011) and DA deinnervation contributes to basal ganglia circuit dysfunction and consequent motor deficts of Parkinson's disease (PD) (Carlsson, 2002; Mallet et al., 2008; Wichman and…”
Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation (2013, background): “a, Schematic of TCSPC-based fibre-optic system, showing the single-mode fibre for excitation (1), multi-mode fibre for photon collection (2), optional electrophysiological cable (3), right lever (4), food magazine (5), and left lever (6).”
Neural basis of reinforcement learning and decision making. (2012, background): “…1993, Schultz 2006, Haber et al. 2000, Haber & Knutson 2010), and multiple types of dopamine receptors in the striatum can modulate the plasticity of corticostriatal synapses accordingo the relative timing of presynaptic vs. postsynaptic action potentials (Shen et al. 2008, Gerfen & Surmeier 2011).”