Serine/threonine phosphatases: mechanism through structure.

By Yigong Shi. Cell, 2009

1,478 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) (2017, neutral): “PPP and PMP groups are responsible for most dephosphorylation reactions of phosphoserine and phos-photreonine (pSer/pThr) and they can also dephosphorylate phosphotyrosine (pTyr) (35,36).”
SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. (2013, background): “, Shinzato, M., Machida, N., Uezato, H., Nonaka, S. and Kariya, K. (2004) The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton. J. Biol. Chem. 279, 49488–49496 100 Huang, E. J. and Reichardt, L. F. (2003) Trk receptors: roles in neuronal signal transduc”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “…specificity is achieved through docking of the phosphatase complex at a site distant from the dephosphorylated amino acid (Roy & Cyert, 2009; Shi, 2009); (iii) the targeted sequences are highly charged, and many of the interacting compounds are not hydrophobic enough to cross the membrane…”