The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

By Joseph Landry, A. Sutton, S. Tafrov, Ryan C Heller, J. Stebbins, L. Pillus, R. Sternglanz. Proceedings of the National Academy of Sciences of the United States of America, 2000

987 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/c67e3e124e937f3358dd7e8341394caf41d1dc69

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. D. Sinclair
3. M. Haigis
4. E. Verdin
5. Laura Bordone
6. F. Picard
7. M. McBurney
8. Su-Ju Lin

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. M. Haigis
4. E. Verdin
5. Laura Bordone
6. R. Mostoslavsky
7. F. Picard
8. M. McBurney

In Physiology

1. L. Guarente
2. D. Sinclair
3. E. Verdin
4. M. Haigis
5. R. Mostoslavsky
6. F. Alt
7. Brian J. North
8. W. Gu

Citations in the corpus

• Calorie restriction, SIRT1 and metabolism: understanding longevity (2005, background): “Sir2 was shown to possess a remarkable enzymatic activity — NAD-dependent HISTONE-DEACETYLASE activit”
• SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. (2006, background): “3, top panel) (Landry et al. 2000).”
• Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002, background): “Sir2 exhibits an NAD-dependent histone deacetylase activity that is conserved among Sir2-family members and is required for chromatin silencing and lifespan extensio”
• Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence (2002, background): “Recent studies have shown that ySir2 and its homologs possess NAD-dependent HDAC activity (Imai et al., 2000; Landry et al., 2000; Smith et al., 2000).”
• The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3 (2001, background): “It has previously been shown that the yeast silencing protein Sir2 requires NAD cofactor to become an active deacetylase (24, 32 , 46).”
• Calorie restriction--the SIR2 connection. (2005, background): “The enzymatic activity of the SIR2 product was found r Tto be a highly unusual one, NAD-dependent histone deacetylase (Imai et al., 2000; Landry et al., 2000; Smith w eet al., 2000).”
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, neutral): “In 1999, Frye discovered that mammalian sirtuins metabolize NAD+ (Frye, 1999), then the Guarente and Sternglanz labs revealed that yeast Sir2 is an NAD+-dependent histone deacetylase (Imai et al., 2000; Landry et al., 2000).”
• Histone deacetylases and cancer: causes and therapies (2001, background): “Three classes of HDAC have been identified that might be involved in modelling the structure of chromati”