The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3

By M. Guenther, Orr G. Barak, Mitchell A. Lazar. Molecular and Cellular Biology, 2001

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Class I histone deacetylases (HDAC1–3) are histone lysine delactylases (2021, background): “The activity of the HDACs is enhanced when engaged in their cognate complexes (48), and standard recombinant”
Transcriptional complexes engaged by apo‐estrogen receptor‐α isoforms have divergent outcomes (2004, background): “Indeed, Sin3 complexes containing either NCoR or SMRT can recruit either HDAC1, 3 or 7 (Heinzel et al, 1997; Kao et al, 2000; Guenther et al, 2001).”
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “The N-CoR and SMRT corepressors stimulate the deacetylase activity of HDAC3 through their SANT domain”
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation (2005, neutral): “Anti-dimethyl K4H3 (12-460), anti-monomethyl K4H3”
HES and HERP families: Multiple effectors of the notch signaling pathway (2003, background): “N-CoR has been recently shown to associate with HDAC3 (Wen et al., 2000; Guenther et al., 2001), but not with the Sin3/HDAC1 complex (Guenther et al.”
The SANT domain: a unique histone-tail-binding module? (2004, background): “Interestingly, the binding of SMRT and N-CoR to the catalytic HDAC3 subunit is necessary and sufficient to form an active deacetylas”
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes (2011, background): “The NCoR complex is the major corepressor for nuclear receptor”