Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP.

By U. Frey, R. Morris. 1998

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Synaptic weight decay with selective consolidation enables fast learning without catastrophic forgetting (2019, background): “A: Frey and Morris (1997), B: Sajikumar and Frey (2003), C1: Frey and Morris (1997), C2-C4: Sajikumar and Frey (2004), D1: Frey and Morris (1998), D2-D4: Sajikumar and Frey (2004) Fast learning deteriorates pattern discriminability when mixing easy and dif-ﬁcult tasks So far we have shown how fast…”
Locally dynamic synaptic learning rules in pyramidal neuron dendrites (2007, unknown): “Synaptic-tagging-based plasticity occurs both when the ‘weak’ stimulus precedes and when it follows the ‘strong’ stimulus 37,38 .”
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB (2012, background): “The “synapt ic tag” model has been supported by a number of studies both in the rodent hippocampus [73,76-78] and Aplysia [63,72].”
The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP (2011, methodology): “Analogous to STC measured at a population level (Frey and Morris, 1998), STC at the single-spine level is temporally bidirectional as GLU stimulation given to one spine (E1) prior to GLU+FSK stimulation given to a second spine (L2; Figure 2J) resulted in the expression of L-LTP at both spines (Figur”
State Based Model of Long-Term Potentiation and Synaptic Tagging and Capture (2009, background): “4a (strong before weak), consistent with data [13].”
Making memories last: the synaptic tagging and capture hypothesis (2010, background): “The prolonged but temporary activity of particular kinases may account for the limited lifespan of the tagged state — approximately 90 min as revealed by 'weak before strong' brain slice protocol”
Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory. (2003, background): “A new perspective on these ideas is the synaptic tagging hypothesis of memory trace formation (Frey & Morris 1997, 1998a,b; Morris & Frey 1997; Dudai & Morris 2001).”
Reward-related fMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation (2005, background): “…is associated with synaptic plasticity processes in the hippocampus for which the induction of long-term potentiation (LTP) is generally believed to play an important role (Morris and Frey, 1997; Frey and Morris, 1998; Morris et al., 2003; Pittenger and Kandel, 2003; Straube et al., 2003a, 2003b).”
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas (2006, background): “The original framework due to Frey & Morris (1998b) implies that it is necessary, whereas that due to Lisman & Grace (2005) indicates that novelty may drive a more diffuse upregulation of neuromodulatory afferents.”