Locally dynamic synaptic learning rules in pyramidal neuron dendrites

By Christopher D. Harvey, Karel Svoboda. 2007

636 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Modeling the dynamic interaction of Hebbian and homeostatic plasticity. (2014, methodology): “We assume the output activity is given by y =wx and take the input activity x to be constant in each condition, x = 1 for normal visual experience, and x 1 under MD (for simplicity we take activities and weights to be unitless numbers).”
Models of Metaplasticity: A Review of Concepts (2015, background): “More importantly, homeostatic regulation or plasticity thresholds exhibit variability and affect predominantly neighboring synapses in vivo (Harvey and Svoboda, 2007).”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (neutral): “, 2010) and that activity-initiated signaling cascades within the postsynaptic spines and dendrites interact locally with other spines (Harvey and Svoboda, 2007).”
Plasticity of Cortical Excitatory-Inhibitory Balance (2015, background): “Other types of modifications to cortical synapses in vivo and in vitro also occur, including heterosynaptic LTP (Dorrn et al. 2010, Meliza & Dan 2006, Royer & Paré 2003) and sensitization of neighboring inputs, lowering the threshold for STDP induction (Harvey & Svoboda 2007).”
Spontaneous network activity and synaptic development (2013, neutral): “…2004), but recent studies revealed that activity-dependent changes in one synapse can shift the plasticity threshold of neighboring connections (Harvey and Svoboda 2007; Harvey and 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA…”
Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses (2009, background): “Also, the STDP rule can be dynamically regulated by the activity of adjacent synapses (6) or by the activation of -adrenergic receptors and M1 muscarinic cholinergic receptor (7, 8).”
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012, background): “Insertion of additional receptors therefore is likely to affect the ultrastructure of the synapse, and in fact, spines associated with synapses that underwent LTP enlarge (Matsuzaki et al. 2004; Harvey and Svoboda 2007; Holtmaat and Svoboda 2009; Kasai et al. 2010).”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “Potentiation of a single synapse on a cultured neuronal dendrite lowers the threshold for LTP induction at neighboring synapses (Harvey and Svoboda, 2007) and encourages local emergence of new spines (Engert and Bonhoeffer, 1999; Maletic-Savatic et al., 1999; Ostroff et al., 2002; Nagerl et al.,…”
Metaplasticity: tuning synapses and networks for plasticity (2008, background): “This mechanism seems to be well-suited for promoting bands of localized LTP on the dendrites of postsynaptic neuron”
Dendritic excitability and synaptic plasticity. (2008, neutral): “There are some reports, however, showing that input specificity breaks down for synapses that are on the order of tens of microns apart, most likely due to lateral spread inside the dendritic branch of some messenger molecule (200, 277), or due to presynaptically expressed LTP mediated by nonspecifi”