Innate immunity in the central nervous system.

By R. Ransohoff, Melissa A Brown. Journal of Clinical Investigation, 2012

972 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/897e5aa7f4f7befa152ce28420686cbc86d3ce85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. O’Banion
2. Guo-Yuan Yang
3. G. Harry
4. Yongting Wang
5. Chao Gao
6. Shengdi Chen
7. Yuyan Tan
8. Jingwen Jiang

In Neurology

1. M. O’Banion
2. Guo-Yuan Yang
3. G. Harry
4. Yongting Wang
5. Chao Gao
6. Shengdi Chen
7. Yuyan Tan
8. Jingwen Jiang

Citations in the corpus

• Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Using a full array of immune receptors, such as toll-like receptors (TLRs), nucleotidebinding oligomerization domains (NODs), NOD-like receptors, and many scavenger receptors [10,11], microglia (as well as other CNS cells, such as astrocytes) are able to recognize harmful stimuli and respond by prod”
• Microglial M1/M2 polarization and metabolic states (2016, background): “They recognize harmful stimuli using a full array of immune receptors, such as tolllike receptors (TLRs), nucleotide-binding oligomerization domains (NODs), NOD-like receptors and many scavenger receptors (SRs; Ransohoff and Perry, 2009; Ransohoff and Brown, 2012).”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “Activation of pattern recognition receptors (PRRs) via pathogenassociated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) triggers microglia M1 phenotype.(108) Microglia display a diverse set of toll-like receptors (TLRs), whereas astrocytes primarily express TLR3, with mi”
• Canonical Nlrp3 inflammasome links systemic low grade inflammation to functional decline in aging (2013, positive): “Astrogliosis is an important mechanism that contributes to age-related functional decline and dementia (Ransohoff and Brown, 2012).”
• The biphasic function of microglia in ischemic stroke (2017, positive): “Indeed, emerging evidence indicated that there exists a functional communication between microglia and astrocytes, which is crucial for the innate immune response in the brain (Ransohoff and Brown, 2012).”