CREB required for the stability of new and reactivated fear memories

By S. Kida, Sheena A. Josselyn, S. Ortiz, J. Kogan, Itzamarie Chevere, S. Masushige, Alcino J. Silva. Nature Neuroscience, 2002

650 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c4d11fc7160f6688bf0e9b935f9f875699ce50d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Y. Dudai
2. Sheena A. Josselyn
3. Paul W. Frankland
4. S. Tonegawa
5. Christopher Pittenger
6. Dennis S. Charney
7. R. Duman
8. Akinobu Suzuki

In Cognitive Neuroscience

1. Y. Dudai
2. Paul W. Frankland
3. Sheena A. Josselyn
4. S. Tonegawa
5. Akinobu Suzuki
6. Ted Abel
7. H. Pape
8. Douglas A. Baxter

In Neurology

1. Y. Dudai
2. S. Tonegawa
3. Sheena A. Josselyn
4. H. Pape
5. Denis Paré
6. Paul W. Frankland
7. R. Duman
8. Dennis S. Charney

Citations in the corpus

• Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures (2004, background): “In contrast, as shown previously (Kida et al., 2002), reconsolidation after a longer reexposure (3 min) was disrupted by ANI (F (1,18) ϭ 27.83; p Ͻ 0.05) (Fig.”
• The neurobiology of consolidations, or, how stable is the engram? (2004, methodology): “Kida et al. (2002) used transgenic mice with an inducible and reversible suppressor of the transcription factor CREB (see Synaptic Consolidation, above), and found that CREB is crucial for the consolidation of long-term contextual fear conditioning as well as for the stability of retrieved…”
• Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation (2007, background): “Much research suggests that CREB and CREB-mediated transcription (Bourtchuladze et al., 1994; Kogan et al., 1997; Gass et al., 1998; Josselyn et al., 2001, 2004; Barco et al., 2002; Graves et al., 2002; Kida et al., 2002; Pittenger et al., 2002; Balschun et al., 2003) is involved in both hippocampus”
• Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, positive): “MAPKs translocated into the nucleus phosphorylate transcription factors, such as cAMP response element binding protein (CREB).”
• Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “The cAMP responseelement binding protein requirement suggests that nuclear protein synthesis is necessary (177).”
• Memory engrams: Recalling the past and imagining the future (2020, background): “This result was replicated and generalized to several types of memory (156, 236, 237).”